喉癌组织中KAI1和CD44v3的表达与颈淋巴结转移的研究  

The Relationship of Lymph Node Metastasis and the Expression of KAI1,CD44v3 in Squamous Cell Carcinoma of Laryngeal

作　　者：郭其云[1] 

机构地区：[1]潍坊市人民医院耳鼻喉科,山东潍坊261041

出　　处：《潍坊医学院学报》2015年第3期194-196,共3页Acta Academiae Medicinae Weifang

摘　　要：目的探讨喉癌组织中KAI1和CD44v3的表达与颈部淋巴结转移的关系。方法采用免疫组织化学(S-P)法,分别检测40例喉癌患者、30例正常咽喉黏膜组织中KAI1和CD44v3的表达水平,分析两者与患者年龄、临床分期、病理分级、有无淋巴结转移的关系。结果 KAI1在对照组的阳性表达率为93.3%(28/30),在喉癌组织中阳性表达率为62.5%(25/40),二者之间差异有统计学意义(x^2=8.86,P<0.01);CD44v3在对照组的阳性表达率为23.3%(7/30),在喉癌组织中阳性表达率为75%(30/40),二者之间差异有统计学意义(x^2=18.36,P<0.01);而KAI1的表达与分化程度、临床分期无关(P>0.05),与是否有淋巴结转移有关(P<0.05);CD44v3的表达与临床分期及是否有淋巴结转移有关(P<0.05),而与分化程度无关。结论 KAI1,CD44v3的异常表达与喉癌的侵袭和转移相关。Objective To observe the expressions of KAI1 and CD44v3 in laryngeal carcinoma and its rela-tionship with lymph nodes metastasis.Methods The technology of immunohistochemistry（ S-P） was used to detect the protein expressions of KAI1,CD44v3 in the 40 cases of laryngeal carcinoma and 30 cases normal mucosa respectively.In addition,several clinic pathological features were analyzed.Results The rate of positive expression of KAI1 in the con-trol group was 93.3%（28/30）,that in laryngeal carcinoma was 62.5%（25/40）,both were statistically significant（χ2 =8.86,P〈0.01）.The rate of positive expression of CD44v3 in the control group was 23.3%（7/30）,that in laryngeal carcinoma was 75%（30/40）,both were statistically significant（χ2 =18.36,P〈0.01）.While the expression of KAI1 was incorrelate with the clinical stage and the degree of differentiation（ P〉0.05） ,but correlated with lymph nodes me-tastasis（P〈0.05）.The expression of CD44v3 was correlated with the clinical stage and lymph nodes metastasis（P〈0. 05）,not the degree of differentiation.Conclusion The abnormal expression of KAI1,CD44v3 in laryngeal carcinoma is correlated with invasion and metastasis of laryngeal carcinoma.

关 键 词：喉肿瘤 KAI1 CD44 V3 淋巴结转移 免疫组化 

分 类 号：R739.65[医药卫生—肿瘤]