OHAA安全性毒理学评价  

Toxicological Assessment of OHAA

作　　者：陆健康 李述刚 唐翠 艾明艳 

机构地区：[1]南疆特色农产品深加工兵团重点实验室,新疆阿拉尔843300

出　　处：《塔里木大学学报》2015年第1期141-144,共4页Journal of Tarim University

摘　　要：目的:研究新型保鲜材料环氧乙烷高级脂肪醇(OHAA)的毒理学安全性。方法:通过小鼠急性毒性试验、小鼠精子畸形试验及小鼠骨髓细胞微核试验对OHAA进行毒理安全性评价。结果:OHAA对昆明小鼠的急性经口LD50>21.5 g/(kg·bw),判属无毒物;OHAA在5.0 g/(kg·bw)剂量范围内,不会造成小鼠精子畸形;骨髓微核发生率与阴性对照组比较差异不显著(p>0.01)。结论:OHAA属实际无毒,且在一定剂量范围内,小鼠精子畸形及小鼠骨髓细胞微核试验结果均为阴性,表明OHAA可以作为一种潜在新型保鲜材料在果蔬和禽蛋保鲜中应用。Objective： To study the toxicological safety of a new fresh keeping material OHAA. Methods： Acute toxicity test,Mice sperm abnormality test and bone marrow cell micronucleus test were taken for toxicological evaluating on the safety of OHAA. Results：Acute toxicity test in mice demonstrated non-toxicity of OHAA due to its LD50 more than 21. 5 g /（kg·bw）; OHAA would not cause the mouse sperm malformation in the dose range of 5. 0 g /（kg · bw）; The incidences of mouse bone marrow micronucleus in all OHAA dose groups did not exhibit a significant difference（p 〉0. 01） as compared with the control group. Conclusion： No phenomena of mouse death observed in this experiment suggested that OHAA had no acute toxic effects,both Mice sperm abnormality test and bone marrow cell micronucleus test were negative in a certain dose range,the result indicated that OHAA could be applied in the preservation of fruits,vegetables and eggs as a potential new preservation material.

关 键 词：OHAA 安全性评价 保鲜 

分 类 号：R114[医药卫生—卫生毒理学]