The role of the microenvironment on the fate of adult stem cells  

作　　者：DONG Liang HAO HaoJie HAN WeiDong FU XiaoBing 

机构地区：[1]Institute of Basic Medicine Science, College of Life Science, Chinese PLA General Hospital

出　　处：《Science China(Life Sciences)》2015年第7期639-648,共10页中国科学（生命科学英文版）

基　　金：supported in part by the National Basic Research Program of China(2012CB518103,2012CB518105);National High Technology Research and Development Program of Ministry of Science and Technology of China(2013AA020105,2012AA020502);National Natural Science Foundation of China(81121004,81230041,31400822)

摘　　要：Adult stem cells(SCs) exist in all tissues that promote tissue growth, regeneration, and healing throughout life. The SC niche in which they reside provides signals that direct them to proliferate, differentiate, or remain dormant; these factors include neighboring cells, the extracellular matrix, soluble molecules, and physical stimuli. In disease and aging states, stable or transitory changes in the microenvironment can directly cause SC activation or inhibition in tissue healing as well as functional regulation. Here, we discuss the microenvironmental regulation of the behavior of SC and focus on plasticity approaches by which various environmental factors can enhance the function of SCs and more effectively direct the fate of SCs.Adult stem cells （SCs） exist in all tissues that promote tissue growth, regeneration, and healing throughout life. The SC niche in which they reside provides signals that direct them to proliferate, differentiate, or remain dormant; these factors include neighboring cells, the extracellular matrix, soluble molecules, and physical stimuli. In disease and aging states, stable or tran- sitory changes in the microenvironment can directly cause SC activation or inhibition in tissue healing as well as functional regulation. Here, we discuss the microenvironmental regulation of the behavior of SC and focus on plasticity approaches by which various environmental factors can enhance the function of SCs and more effectively direct the fate of SCs.

关 键 词：stem cell MICROENVIRONMENT PLASTICITY FATE 

分 类 号：Q813[生物学—生物工程] X703[环境科学与工程—环境工程]