男性精子异常与染色体异常及Y染色体微缺失的研究  

Study on male sperm abnormalities and chromosomal abnormality and Y chromosome microdeletion

作　　者：曾海燕[1] 吴杰[1] 

机构地区：[1]广东省梅州市人民医院检验科,514031

出　　处：《齐齐哈尔医学院学报》2015年第16期2398-2399,共2页Journal of Qiqihar Medical University

摘　　要：目的研究不育男性的染色体异常和Y染色体微缺失情况。方法对369例无精子症、128例重度少弱精子症患者进行染色体核型分析,并对108例进行Y染色体AZF微缺失检测。结果无精子症组性染色体异常22.73%,常染色体异常6.57%,染色体多态性9.34%;重度少弱精子症组性染色体异常1.56%、常染色体异常1.56%、染色体多态性4.69%;健康对照组染色体多态性2.70%。三组染色体异常比较有统计学意义(P<0.05)。无精子症患者Y染色体微缺失7例(7.69%)。结论男性不育与染色体核型异常及Y染色体微缺失关系密切。Objective To study the chromosomal abnormality and Y chromosome microdeletion of the male with infertility .Methods Karyotype analysis was carried out in sperm disease patients with 369 cases of azoospermia , 128 cases of severe oligospermia , 108 cases were carried out detection of AZF microdeletion on y-chromosome.Results There was 22.73% about the abnormality of chromosome in azoospermia group , 6.57%about abnormal euchromosome , 9.34% about chromosome polymorphism . There was 1.56% about the abnormality of chromosome , 1.56%about abnormal euchromosome , 4.69%about chromosome polymorphism in the patients with severe oligozoospermia group .There was 2.70%about chromosome polymorphism in the healthy control group.There were statistically significant about the chromosome abnormalities （P〈0.05）.There was 7 cases （7.69%） with Y chromosome microdeletions in the azoospermia patients .Conclusions The male sterility is closely related to abnormal chromosome karyotype and Y chromosome microdeletion .

关 键 词：无精子症 少弱精子症 染色体异常 微缺失 

分 类 号：R698.2[医药卫生—泌尿科学]