乳腺癌组织中血管内皮生长因子-D和PTEN的表达及临床意义  

Expressions of vascular endothelial growth factor-D and PTEN in breast cancer tissue and its clinical significance

作　　者：赵云霞[1] 刘恒超[2] 马琳[1] 赵瑾[1] 

机构地区：[1]蚌埠医学院病理生理学教研室,安徽蚌埠233030 [2]蚌埠医学院第一附属医院核医学科,安徽蚌埠233004

出　　处：《蚌埠医学院学报》2015年第6期704-707,共4页Journal of Bengbu Medical College

基　　金：安徽省教育厅高校自然科学研究项目(KJ2013Z206);安徽省教育厅自然科学研究项目(KJ2013B148)

摘　　要：目的:探讨乳腺癌组织中血管内皮生长因子-D(VEGF-D)和10号染色体缺失的磷酸酶及张力蛋白同源物(PTEN)蛋白异常表达的作用及其临床意义。方法:应用免疫组织化学S-P法检测90例乳腺浸润性导管癌和20例乳腺良性增生性病变组织中VEGF-D蛋白和PTEN蛋白的表达;结合临床病理指标进行分析。结果:乳腺癌组织中VEGF-D蛋白和PTEN蛋白表达与良性增生性病变组织中表达差异均有统计学意义(P<0.01)。VEGF-D蛋白阳性表达在淋巴结有无转移、雌激素受体阳性与阴性表达间差异均有统计学意义(P=0.03和P<0.05)。PTEN蛋白的阴性表达在淋巴结有无转移、雌激素受体阳性及阴性表达间差异均有统计学意义(P<0.01)。乳腺癌组织中VEGF-D蛋白与PTEN蛋白表达呈显著负相关关系(P<0.01)。结论:VEGF-D和PTEN蛋白异常表达参与了乳腺癌的浸润和转移;VEGF-D和PTEN表达存在相关性。Objective：To investigate the roles of the aberrant expressions of vascular endothelial growth factor（ VEGF）-D and gene of phosphate and tension homology deleted on chromsome ten（ PTEN） in breast cancer tissue and its clinical significance. Methods：The levels of VEGF-D and PTEN in 90 samples of breast invasive carcinoma tissue, and 20 samples of benign proliferative lesions were detected using immunohistochemical method, the results of which together with the clinical pathological parameters were analyzed. Results：The differences of the levels of VEGF-D and PTEN protein between breast cancer tissue and benign hyperplastic lesions tissue were statistically significant（P〈0. 01）. The differences of the positive expression of VEGF-D protein in the patients with lymph nodes metastasis or without,and positive and negative expression of estrogen receptor were statistically significant（P=0. 03 and P〈0. 05）. The differences of the negative expression of VEGF-D protein in the patients with lymph nodes metastasis or without,and positive and negative expression of estrogen receptor were statistically significant（P〈0. 01）. The level of VEGF-D protein was significantly negative correlation with PTEN in breast cancer tissue（P〈0. 01）. Conclusions：The aberrant expressions of VEGF-D and PTEN are related to the invasion and metastasis of breast cancer. The expressions of VEGF-D and PTEN protein are correlative.

关 键 词：乳腺肿瘤 免疫组织化学 血管内皮生长因子-D 10号染色体缺失的磷酸酶及张力蛋白的同源物 

分 类 号：R737.9[医药卫生—肿瘤]