正常儿童和青少年眼表健康状态观察  

Observation of ocular surface in a normal population of children and adolescence

作　　者：吴元[1] 李海丽[1] 荣蓓[1] 晏晓明[1] 

机构地区：[1]北京大学第一医院眼科视觉损伤与修复教育部重点实验室,100034

出　　处：《中国斜视与小儿眼科杂志》2015年第2期1-4,11,共5页Chinese Journal of Strabismus & Pediatric Ophthalmology

摘　　要：目的观察正常儿童和青少年的眼表健康状态。方法招募健康、无眼表刺激症状的3～18岁儿童及青少年70名,观察眼表健康形态,评估睑缘异常评分、睑板腺评分、角膜上皮荧光素钠染色评分（FL）、泪膜破裂时间（BUT）等眼表指标。按年龄分为儿童组（3～11岁）和青少年组（12～18岁）,分析比较两组各眼表指标的差异。结果 70名受检者中,22名（31.4%）睑缘异常评分≥1分,20名（28.6%）睑板腺评分≥1分;11名（15.5%）角膜上皮荧光素钠着染,评分0.24±0.59分;58名（81.7%）BUT≥10秒,平均9.29±2.28秒。儿童组与青少年组比较,睑缘异常评分较低（χ2=3.86,P〈0.05）,角膜上皮荧光染色评分较高（t=2.259,P〈0.05）,而睑板腺评分、BUT之间差异无统计学意义。结论部分健康、无眼表刺激症状的儿童和青少年人群中可存在睑缘异常和角膜上皮荧光素钠着染的现象。且随着年龄的增长,睑缘异常的比例增加,而角膜上皮损伤呈改善的趋势。Objective To observe the ocular surface of normal children and adolescence. Methods Right eyes of 70 subjects（3～18 years old） without ocular surface irritation were enrolled to observe the lid margin abnormality score, meibomian gland score,fluorescein corneal staining score and break-up time（BUT）. The subjects were divided into children group（3-11 years old） and adolescence group（12-18 years old） and were observed the difference of those parameters of ocular surface between two groups. Results 22 subjects（31.4%） have a lid margin abnormality score of ≥1 and 20 subjects（28.6%） have a meibomian gland score of ≥1. 11 subjects have corneal staining and the average score is 0.24±0.59. 58（81.7%） subjects have a BUT more than 10 s and the average BUT is 9.29±2.28 s. Compared with adolescence group, the children groups have a lower lid margin abnormality score（χ2=3.86,P〈0.05） but a higher fluorescein staining score（t =2.259,P〈0.05）. The meibomian score and BUT haven＇t statistical difference between the children group and adolescence group. Conclusion The lid margin abnormalities and fluorescein staining can be found in normal population of children and adolescence without ocular surface irritation. The lid margin abnormalities become less but the fluorescein corneal staining more with age.

关 键 词：儿童 青少年 眼表 

分 类 号：R770.4[医药卫生—眼科]