乙型肝炎病毒疫苗逃逸株及其研究策略的初步探讨  

Hepatitis B virus vaccine escape mutants and their development strategies

作　　者：陈盼[1] 吴星[1] 梁争论[1] 

机构地区：[1]中国食品药品检定研究院肝炎病毒疫苗室,北京100050

出　　处：《中国生物制品学杂志》2015年第7期755-759,共5页Chinese Journal of Biologicals

基　　金：国家"十二五"艾滋病和病毒性肝炎等重大传染病防治科技国家重大专项(2013ZX09304101)

摘　　要：乙肝疫苗的接种为人类控制乙肝流行做出了巨大贡献,但乙型肝炎病毒(hepatitis B virus,HBV)在疫苗、核苷类药物的筛选压力下易发生突变成为疫苗变异株,可能影响疫苗的保护效果。近期建立的HBV体外感染系统为研究疫苗逃逸株对乙肝疫苗保护人群的潜在威胁提供了工具。本文对HBV疫苗逃逸株及其研究策略进行初步探讨。Prophylactic vaccination against hepatitis B virus（HBV） has got great achievements in hepatitis B disease control worldwide. Mutants selected by vaccine and nucleoside analogs may emerge as vaccine escape mutants and affect the efficacy of hepatitis B vaccine. The in vitro HBV infection system developed recently provides a tool for research on the potential risk of HBV vaccine escape mutants to the vaccinated population. HBV vaccine escape mutants and their development strategies are investigated primarily in this paper.

关 键 词：乙型肝炎病毒 乙肝疫苗 突变株 

分 类 号：R373.21[医药卫生—病原生物学] R392-33[医药卫生—基础医学]