线粒体tRNA突变与高血压关系的研究进展  

Relationshipof mitochondrial tRNA mutationwith development of hypertension：aresearchprogress

作　　者：路艳[1] 赵玉生[2] 李宗斌[2] 

机构地区：[1] 解放军总医院南楼临床部综合外一科,北京100853 [2] 解放军总医院心血管内科,北京100853

出　　处：《中华老年多器官疾病杂志》2015年第6期477-480,共4页Chinese Journal of Multiple Organ Diseases in the Elderly

基　　金：中国博士后基金（20080431356）;国家自然科学基金项目（81170249,30700305）;北京市科技新星计划（2008A064）

摘　　要：线粒体基因突变与多种疾病的发生有关，虽然转移RNA（tRNA）基因只占整个线粒体基因组的10%，但它们却是研究线粒体基因突变与疾病发生关系的热点。既往高血压遗传学的研究主要集中在核基因方面，近年来研究发现线粒体DNA突变可能参与原发性高血压（EH）的发生与发展，且越来越多的线粒体tRNA也被报道与EH的发生和发展密切相关。本文对线粒体tRNA突变与高血压发病的关系及其机制进行了综述。Mitochondrial DNA mutation is associated with a variety of diseases. Althoughonly constituting 10% of the entire mitochondrial genome,the transfer RNA（tRNA） geneshave become a hotspotin the study concerning the relationship of the mitochondrial gene mutation with diseases. Previous studies on the genetics of hypertension mainlyconcentrated in the nuclear genes, butrecent studies found that mitochondrial DNA mutations may be involved in the occurrence and development of essential hypertension （EH）.What’s more, much evidence indicated that close association was found between mitochondrial tRNA with theEH occurrence and development.In this article, we summarized the relationship between themitochondrial tRNA mutation and pathogenesis of hypertension, andreviewed the underlyingmechanism.

关 键 词：线粒体 TRNA 原发性高血压 基因突变 

分 类 号：R394.112[医药卫生—医学遗传学] R544.1[医药卫生—基础医学]