Familial colorectal cancer screening: When and what to do?  

作　　者：Giovanna Del Vecchio Blanco Omero Alessandro Paoluzi Pierpaolo Sileri Piero Rossi Giuseppe Sica Francesco Pallone 

机构地区：[1]Department of Systems Medicine,Gastroenterology Unit,University Tor Vergata [2]Department of Surgery,University Tor Vergata [3]Department of Experimental Science and Surgery,University Tor Vergata

出　　处：《World Journal of Gastroenterology》2015年第26期7944-7953,共10页世界胃肠病学杂志（英文版）

摘　　要：Colorectal cancer(CRC) is the third leading cause of death worldwide and represents a clinical challenge.Family members of patients affected by CRC have an increased risk of CRC development.In these individuals,screening is strongly recommended and should be started earlier than in the population with average risk,in order to detect neoplastic precursors,such as adenoma,advanced adenoma,and nonpolypoid adenomatous lesions of the colon.Fecal occult blood test(FOBT) is a non invasive,widespread screening method that can reduce CRC-related mortality.Sigmoidoscopy,alone or in addition to FOBT,represents another screening strategy that reduces CRC mortality.Colonoscopy is the best choice for screening highrisk populations,as it allows simultaneous detection and removal of preneoplastic lesions.The choice of test depends on local health policy and varies among countries.Colorectal cancer(CRC) is the third leading cause of death worldwide and represents a clinical challenge.Family members of patients affected by CRC have an increased risk of CRC development.In these individuals,screening is strongly recommended and should be started earlier than in the population with average risk,in order to detect neoplastic precursors,such as adenoma,advanced adenoma,and nonpolypoid adenomatous lesions of the colon.Fecal occult blood test(FOBT) is a non invasive,widespread screening method that can reduce CRC-related mortality.Sigmoidoscopy,alone or in addition to FOBT,represents another screening strategy that reduces CRC mortality.Colonoscopy is the best choice for screening highrisk populations,as it allows simultaneous detection and removal of preneoplastic lesions.The choice of test depends on local health policy and varies among countries.

关 键 词：COLONOSCOPY Colorectal cancer SCREENING FECAL OCCULT blood test Advanced ADENOMA Firstdegreerelative SIGMOIDOSCOPY 

分 类 号：R735.34[医药卫生—肿瘤]