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The gut-eye axis:from brain neurodegenerative diseases to age-related macular degeneration
《Neural Regeneration Research》2025年第10期2741-2757,共17页Qianzi Jin Suyu Wang Yujia Yao Qin Jiang Keran Li 
supported by the National Natural Science Foundation of China,No.82171080;Nanjing Medical Science and Technology Development Project,No.YKK23264;Postgraduate Research&Practice Innovation Program of Jiangsu Province,Nos.JX10414151,JX10414152(all to KL)。
Age-related macular degeneration is a serious neurodegenerative disease of the retina that significantly impacts vision.Unfortunately,the specific pathogenesis remains unclear,and effective early treatment options are...
关键词：age-related macular degeneration biological agents blinding eye disease dietary nutrition fecal microbial transplantation gut-eye axis intestinal flora METABOLITE MICROECOLOGY neurodegenerative disease 
Microbial fermentation of blue honeysuckle(Lonicera caerulea L.)polyphenol promotes insulin secretion and intervenes in obesity by promoting short-chain fatty acids production
《Food Science and Human Wellness》2025年第4期1449-1468,共20页Fangyi Pei Xinbo Cao Yanxin Ren Liangyang Mao Yueyi Liu Jingping Ge Wenxiang Ping 
supported by the Key Program of Heilongjiang Provincial Natural Science Foundation of China(ZD2020C008);the National Natural Science Foundation of China(32071519);the Heilongjiang University Graduate Innovation Research Project(YJSCX2022-031HLJU);the Qiqihar Science and Technology Plan Joint Guidance Project(LSFGG-2022037);Scientific Research Project of Ecological Environment Protection of Heilongjiang Provincial Department of Ecological Environment(HST2022TR004)。
During obesity treatment,clinicians have been burdened by the ever-increasing number of patients and the side effects of drug treatment.Finding new plant-derived active ingredients as an intervention for obesity has b...
关键词：OBESITY Blue honeysuckle POLYPHENOL Short-chain fatty acids In vitro fecal fermentation 
Factors associated with false fecal immunochemical test results in colorectal cancer screening
《World Journal of Gastrointestinal Oncology》2025年第4期131-143,共13页Shu-Yuan Wang Xue-Tao Dong Zhen Yuan Lei-Xin Jin Wei-Feng Gao You-Kui Han Ke-Min Ni Zhao-Ce Liu Jun-Ying Wang Xiao-Meng Wei Xiao-Min Su Xi Peng Chun-Ze Zhang 
Supported by Natural Science Foundation of Tianjin,No.21JCZDJC00060 and No.21JCYBJC00180;Tianjin Health and Medical Science and Technology Project,No.TJWJ2023QN040;National Key Research and Development Program,No.2017YFC1700606 and No.2017YFC1700604.
BACKGROUND Certain subgroups are at an increased risk of false fecal immunochemical test(FIT)results;however,related studies are limited,and the available evidence is conflicting.AIM To evaluate factors associated wit...
关键词：Fecal immunochemical test Advanced colorectal neoplasm False positive False negative Colorectal cancer screening 
Multi-omics reveals the associations among the fecal metabolome,intestinal bacteria,and serum indicators in patients with hepatocellular carcinoma
《World Journal of Gastroenterology》2025年第15期109-130,共22页Jing Feng Jun-Ping Wang Jian-Ran Hu Ping Li Pin Lv Hu-Cheng He Xiao-Wei Cheng Zheng Cao Jia-Jing Han Qiang Wang Qian Su Li-Xin Liu 
Supported by the Department of Science and Technology of Shanxi Province,No.20210302124369;the Health Commission of Shanxi Province,No.2021116;Shanxi Administration of Traditional Chinese Medicine,No.2024ZYY2C054.
BACKGROUND Hepatocellular carcinoma(HCC),the predominant form of primary liver cancer,is a key contributor to cancer-related deaths globally.However,HCC diagnosis solely based on blood biochemical markers lacks both s...
关键词：Hepatocellular carcinoma Fecal metabolomics Intestinal bacteria Correlation analysis Non-targeted liquid chromatography-mass spectrometry 
Machine learning algorithms reveal gut microbiota signatures associated with chronic hepatitis B-related hepatic fibrosis
《World Journal of Gastroenterology》2025年第16期30-48,共19页Ying Zhu Shi-Yu Geng Yao Chen Qing-Jing Ru Yi Zheng Na Jiang Fei-Ye Zhu Yong-Sheng Zhang 
Supported by the Zhejiang Provincial Natural Science Foundation,No.LZ22H270001.
BACKGROUND Hepatic fibrosis(HF)represents a pivotal stage in the progression and potential reversal of cirrhosis,underscoring the importance of early identification and therapeutic intervention to modulate disease tra...
关键词：Chronic hepatitis B virus infection Hepatic fibrosis Liver stiffness Fecal microbiomes Serum intestinal mucosal barrier 
Tuna dark muscle peptides modulate host iron metabolism in the intestine through the gut microbiota and ameliorate iron deficiency anemia
《Food Science and Human Wellness》2025年第2期729-739,共11页Jiaojiao Han Jiayi Xiong Zhixiang Bai Yang Qin Chenyang Lu Jun Zhou Ye Li Tinghong Ming Zhen Zhang Xiurong Su 
sponsored by the Natural Science Foundation of Zhejiang Province(LQ22D060002 and LTGC23C190001);Fund of State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products(ZS20190105);General Project of Zhejiang Provincial Department of Education(Y202146257);K.C.Wong Magna Fund of Ningbo University。
Iron deficiency anemia(IDA)is a nutritional deficiency disease with a high incidence rate worldwide.Bioactive peptides are safe and effective,have multiple functions and can serve as potential candidates for alleviati...
关键词：Iron deficiency anemia PEPTIDES Gut microbiota Fecal transplantation microbiota 
Fecal methylated syndecan-2(SDC2)testing for early screening of colorectal cancerous and precancerous lesions:A real-world retrospective study in China
《Cancer Pathogenesis and Therapy》2025年第1期60-67,共8页Boyu Qin Haitao Niu upeng Qiu Hongfeng Zhou Peng Lyu 
Background:Colorectal cancer(CRC)is a major public health concern and the second leading cause of cancerrelated deaths worldwide.However,challenges remain in deploying effective screening strategies for early-stage CR...
关键词：Colorectal cancer Syndecan-2 DNA methylation DIAGNOSIS 
Effects of Bifidobacterium lactis BLa80 on fecal and mucosal flora and stem cell factor/c-kit signaling pathway in simulated microgravity rats
《World Journal of Gastroenterology》2025年第1期93-109,共17页Ping Zhang Ying Zhu Pu Chen Tong Zhou Zhe-Yi Han Jun Xiao Jian-Feng Ma Wen Ma Peng Zang Ying Chen 
BACKGROUND Simulated microgravity environment can lead to gastrointestinal motility disturbance.The pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor(SCF)/c-kit signaling p...
关键词：Simulated microgravity RAT Intestinal flora Gastrointestinal motility Stem cell factor/c-kit signaling pathway 
Fecal siderophore genes are potential biomarkers for ulcerative colitis
《Chinese Medical Journal》2025年第1期99-101,共3页Jingshuang Yan Rongrong Ren Zhengpeng Li Wanyue Dan Xinyi Ma Xiaohan Zhang Xiaoyan Chi Lihua Peng Yunsheng Yang 
Ulcerative colitis(UC)and Crohn’s disease(CD)are chronic inflammatory bowel diseases(IBDs)with largely unclear etiologies and complex pathogeneses.The pathogenesis of UC has been linked to an imbalance in the gut mic...
关键词：ulcerative colitis chronic inflammatory bowel diseases Crohn s disease gut microbiotaincluding fecal siderophore genes mucosal biopsy pathologywhich 
Fecal bacterial communities of the platypus (Ornithorhynchus anatinus) reflect captivity status—Implications for conservation and management
《Integrative Zoology》2024年第6期1211-1223,共13页Ashley M.DUNGAN Jessica L.THOMAS 
funded by an Environmental Microbiology Researcher Initiative Grant(to Ashley M.Dungan)。
The duck-billed platypus(Ornithorhynchus anatinus)is currently listed as near-threatened.A key part of the conservation strategy for this species is its captive maintenance;however,captive animals often have dysbiotic...
关键词：CAPTIVITY CONSERVATION host-associated MONOTREME SYMBIOSIS 
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