Hepatitis C cirrhosis: New perspectives for diagnosis and treatment  

作　　者：Vikas Khullar Roberto J Firpi 

机构地区：[1]Department of Medicine,University of Florida College of Medicine [2]Section of Hepatobiliary Diseases and Trans-plantation,University of Florida College of Medicine

出　　处：《World Journal of Hepatology》2015年第14期1843-1855,共13页世界肝病学杂志（英文版）（电子版）

摘　　要：Chronic hepatitis C infection is the leading cause of chronic liver disease, cirrhosis, hepatocellular carcinoma as well as the primary indication for liver transplantation in the United States. Despite recent advances in drugs for the treatment of hepatitis C, predictive models estimate the incidence of cirrhosis due to hepatitis C infection will to continue to rise for the next two decades. There is currently an immense interest in the treatment of patients with fibrosis and early-stage cirrhosis as treatment can lead to decrease in the rates of decompensated cirrhosis, hepatocellular carcinoma and need for liver transplantation in these patients. The goal of this paper is to provide clinicians and health care professionals further information about the treatment of patients with hepatitis C infection and cirrhosis. Additionally, the paper focuses on the disease burden, epidemiology, diagnosis and the disease course from infection to treatment. We provide an overview of multiple studies for the treatment of chronic hepatitis C infection that have included patients with cirrhosis. We also discuss the advantages and disadvantages of treatment in cirrhotic patients and focus on the most up to date guidelines available for treatment.Chronic hepatitis C infection is the leading cause ofchronic liver disease, cirrhosis, hepatocellular carcinomaas well as the primary indication for livertransplantation in the United States. Despite recentadvances in drugs for the treatment of hepatitis C,predictive models estimate the incidence of cirrhosisdue to hepatitis C infection will to continue to rise forthe next two decades. There is currently an immenseinterest in the treatment of patients with fibrosis andearly-stage cirrhosis as treatment can lead to decreasein the rates of decompensated cirrhosis, hepatocellularcarcinoma and need for liver transplantation in thesepatients. The goal of this paper is to provide cliniciansand health care professionals further information aboutthe treatment of patients with hepatitis C infection andcirrhosis. Additionally, the paper focuses on the diseaseburden, epidemiology, diagnosis and the disease coursefrom infection to treatment. We provide an overview ofmultiple studies for the treatment of chronic hepatitisC infection that have included patients with cirrhosis.We also discuss the advantages and disadvantages oftreatment in cirrhotic patients and focus on the most upto date guidelines available for treatment.

关 键 词：CIRRHOSIS Diagnosis Treatment Simeprevir Sofosbuvir Ledipasvir LIVER TRANSPLANTATION HEPATITISC VIRUS 

分 类 号：R512.63[医药卫生—内科学] R575.2[医药卫生—临床医学]