四季感冒片中3味药材超临界CO2复方萃取物挥发性成分分析  

Analysis of the Volatile Constituents of the Compound Extract from 3 Medicinal Materials in Siji Ganmao Tablet by Supercritical CO_2 Fluid Extraction

作　　者：乔越[1] 于莲[1] 焦淑清[1] 

机构地区：[1]佳木斯大学药学院/黑龙江省生物药制剂重点实验室,黑龙江佳木斯154007

出　　处：《中国药房》2015年第24期3439-3441,共3页China Pharmacy

摘　　要：目的:分析四季感冒片中紫苏叶、陈皮、荆芥的超临界CO2复方萃取物挥发性成分。方法:采用超临界CO2萃取技术萃取四季感冒片中的3味药材的挥发性成分,采用气相色谱-质谱法对复方提取物进行成分分析。结果:超临界CO2复方提取法的提取率为2.21%,从复方萃取物中分离到21个化合物,鉴定出16个化合物,主要成分是甜橙黄酮(36.56%)和亚油酸(19.52%)。水蒸气蒸馏法提取率为1.035%,从复方提取物中共分离出51个化合物,鉴定出32种化合物,主要成分是D-柠檬烯(62.40%)和侧柏酮(15.49%)。结论:超临界CO2复方萃取技术可提取紫苏叶、陈皮、荆芥3味药材中的挥发性成分,但与水蒸气蒸馏法所得复方挥发油的成分存在差别。OBJECTIVE： To study the volatile constituents of the compound extract from Folium Perillae, Pericarpium Citri and Herb Schizonepetae in Siji Ganmao tablet by supercritical CO2 fluid extraction （SFE-CO2）. METHODS： Supercritical CO2 extraction technology was used to extract the volatile constituents of 3 medical material in Siji Ganmao tablet. The chemical constituents of the compound extract from 3 medicinal materials were analyzed by GC-MS. RESULTS ： The extracting rate of SFE-CO2 was 2.21%, 21 compounds in the compound extract were separated and 16 compounds were identified with the major components of sinensetin （36.56%） and linolic acid （19.52%）. The extracting rate of water steam distillation （SD） was 1.035%, 51 compounds in the compound extract were separated and 32 compounds were identified with the major components of D-limonene（62.40% ） and thujone （15.49 % ）. CONCLUSIONS： The volatile constituents of E perillae, P cCitri and H. Schizonepetae can be compound extracted by SFE-CO2, however, it is different from the constituents of the compound volatile oil by SD.

关 键 词：超临界CO2萃取 复方萃取 气相色谱-质谱联用技术 挥发性成分 水蒸气蒸馏法 

分 类 号：R284.1[医药卫生—中药学] R927.2[医药卫生—中医学]