Dysfunction of autophagy as the pathological mechanism of motor neuron disease based on a patient-specific disease model  

作　　者：Dan-Jing Yang Liang Zhu Jie Ren Rong-Jie Ma Hongwen Zhu Jun Xu 

机构地区：[1]Advanced Institute of Translational Medicine,Tongji University [2]East Hospital,Tongji University School of Medicine [3]Tianjin Hospital,Tianjin Academy of Integrative Medicine

出　　处：《Neuroscience Bulletin》2015年第4期445-451,共7页神经科学通报（英文版）

基　　金：supported by the Ministry of Science and Technology of China (2011CB966200);the National Natural Science Foundation of China (81401053,31471029,81461138037,and 81472141);the National Program for Support of Top-notch Young Professionals;the Program for Young Excellent Talents in Tongji University (2014KJ049);the Public Health Bureau of Tianjin Municipality,China (13KG127)

摘　　要：Autophagy is the main catabolic pathway in cells for the degradation of impaired proteins and organelles. Accumulating evidence supports the hypothesis that dysfunction of autophagy, leading to an imbalance of proteostasis and the accumulation of toxic proteins in neurons, is a central player in the pathogenesis of neurodegenerative diseases such as Alzheimer＇s disease, Parkinson＇s disease, and amyotrophic lateral sclerosis （ALS）. The clinical pathology of ALS is complex and many genes associated with autophagy and RNA processing are mutated in patients with the familial form. But a causal relationship between autophagic dysfunction and ALS has not been fully established. More importantly, studies on the pathological mechanism of ALS are mainly based on animal models that may not precisely recapitulate the disease itself in human beings. The development of human iPSC techniques allows us to address these issues directly in human cell models that may profoundly influence drug discovery for ALS.Autophagy is the main catabolic pathway in cells for the degradation of impaired proteins and organelles. Accumulating evidence supports the hypothesis that dysfunction of autophagy, leading to an imbalance of proteostasis and the accumulation of toxic proteins in neurons, is a central player in the pathogenesis of neurodegenerative diseases such as Alzheimer＇s disease, Parkinson＇s disease, and amyotrophic lateral sclerosis （ALS）. The clinical pathology of ALS is complex and many genes associated with autophagy and RNA processing are mutated in patients with the familial form. But a causal relationship between autophagic dysfunction and ALS has not been fully established. More importantly, studies on the pathological mechanism of ALS are mainly based on animal models that may not precisely recapitulate the disease itself in human beings. The development of human iPSC techniques allows us to address these issues directly in human cell models that may profoundly influence drug discovery for ALS.

关 键 词：motor neuron disease IPSC AUTOPHAGY amyotrophic lateral sclerosis spinal muscular atrophy 

分 类 号：R744.8[医药卫生—神经病学与精神病学]