Design and Synthesis of 3-Triazolo-coumarins and Their Applications in Scavenging Radicals and Protecting DNA  

作　　者：LIU Zhihui WANG Yingnan SUN Jingbo YANG Yang LIU Qingwen LIU Zaiqun SONG Zhiguang 

机构地区：[1]Hospital of Stomatology, Jilin University, Changchun 130021, P R. China [2]Department of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130012, P 1L China

出　　处：《Chemical Research in Chinese Universities》2015年第4期526-533,共8页高等学校化学研究（英文版）

基　　金：Supported by the National Natural Science Foundation of China（No.90813003）.

摘　　要：In this study, we synthesized a series of 3-triazolo-coumarins and evaluated their antioxidant activities respectively by two methods： trapping 2,2＇-azinobis（3-ethylbenzothiazoline-6-sulfonate） cationic radical（ABTS＋＋） and oxidation of DNA which was induced by Cu2＋/glutathione（GSH）, ·OH and 2,2＇-azobis（2-amidinopropane hydrochloride）（AAPH）. Among the nine 3-triazolo-coumarins, compounds 6c and 6f-6i were synthesized for the first time, which exhibited the capability of terminating radical propagation-chains in oxidation of DNA induced by AAPH. In this study, we found that phenethylamine moiety, hydroxyl and ortho-methoxy are the key groups to en- hance the antioxidant activities of compounds.In this study, we synthesized a series of 3-triazolo-coumarins and evaluated their antioxidant activities respectively by two methods： trapping 2,2＇-azinobis（3-ethylbenzothiazoline-6-sulfonate） cationic radical（ABTS＋＋） and oxidation of DNA which was induced by Cu2＋/glutathione（GSH）, ·OH and 2,2＇-azobis（2-amidinopropane hydrochloride）（AAPH）. Among the nine 3-triazolo-coumarins, compounds 6c and 6f-6i were synthesized for the first time, which exhibited the capability of terminating radical propagation-chains in oxidation of DNA induced by AAPH. In this study, we found that phenethylamine moiety, hydroxyl and ortho-methoxy are the key groups to en- hance the antioxidant activities of compounds.

关 键 词：3-Triazolo-coumarin COUMARIN Free radical Oxidation ANTIOXIDANT DNA 

分 类 号：TS202.3[轻工技术与工程—食品科学] Q523[轻工技术与工程—食品科学与工程]