Hepatoprotective and antioxidant effects of baicalin against CCl4-induced hepatotoxicity  

作　　者：Song Liu Xiaohui Lv Zongxi Sun Ruiqiang Su 

机构地区：[1]Department of Pharmacology, College of Medicine, Wuhan University of Science and Technology, Wuhan 430062, China [2]State Key Laboratory of Gen-eric Pharmaceutical Technology for Traditional Chinese Medicine,Linyi 276006, China [3]Lunan Pharmaceuticai Group Co. Ltd., Linyi 276006, China

出　　处：《Journal of Chinese Pharmaceutical Sciences》2015年第8期538-544,共7页中国药学（英文版）

基　　金：National Key Basic Research and Development Program(Grant No.2012CB724001);the Program of Hubei Provincial Department of Education(Grant No.Q20141105);Research Program of Wuhan University of Science and Technology(Grant No.2012ZX022)

摘　　要：Scutellaria baicalensis is widely cultivated in eastern Asia, particularly in China. In the present study, we isolated baicalin from this plant and studied for its hepatoprotective activity against CCl4-induced oxidative damage in rats. Our findings revealed that baicalin exhibited strong antioxidant activity in vitro. In established in vivo tests, baicalin showed effective protective effects by reducing the elevated levels of glutamate pyruvate transaminase （ALT）, aspartate aminotransferase （AST）, alkaline phosphatase （ALP）, total bilirubin （TB） and malondialdehyde （MDA） against CCl4-induced damage, and it restored the activities antioxidant defense substances, such as superoxide dismutase （SOD）, catalase （CAT） and glutathione （GSH）, toward their normal levels. These data were supplemented with histopathological examination of rat liver sections. The results demonstrated that baicalin could be proposed to protect the liver against CCh-induced oxidative damage in rats, and the possible underlying mechanism of the activity could be due to its free radical-scavenging and antioxidant activity.黄芩在东亚地区尤其是我国有广泛的栽培。采用四氯化碳(CCl4)致大鼠急性肝损伤模型研究黄芩苷的保肝作用。研究发现,黄芩苷表现出较强的体外抗氧化活性。在CCl4致大鼠急性肝损伤模型中,给予黄芩苷可有效降低CCl4引起的肝脏中谷丙转氨酶(ALT)、谷草转氨酶(AST)、碱性磷酸酯酶(ALP),总胆红素(TB)和丙二醛(MDA)含量的升高,同时也提高了抗氧化防御物质超氧化物歧化酶(SOD)、过氧化氢酶(CAT)和谷胱甘肽(GSH)的水平。切片病理观察结果也佐证了这一点。黄芩苷对CCl4致大鼠氧化应激肝损伤有保护作用,而这种保护机制可能与其清除自由基和抗氧化能力有关。

关 键 词：BAICALIN HEPATOPROTECTIVE CCL4 ANTIOXIDANT 

分 类 号：R284[医药卫生—中药学]