乳杆菌仔猪肠道黏膜免疫系统的调控及其分子机制  

Regulation of Intestinal Mucosal Immune System by Lactobacillus in Piglets and Its Molecular Mechanisms

作　　者：马现永[1] 蒋宗勇[1] 王志林[1] 王丽[1] 杨雪芬[1] 吴云鹏[1] 胡友军[1] 

机构地区：[1]广东省农业科学院动物科学研究所农业部华南动物营养与饲料重点实验室国家畜禽育种重点实验室广东省动物育种与营养公共实验室广东省畜禽育种与营养重点实验室,广州510640

出　　处：《动物营养学报》2015年第8期2317-2322,共6页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：现代农业产业技术体系(CARS-36);国家自然科学基金(31472112;31201815);公益性行业科研专项(201403047);省重点实验室支持建设专项(2012A061100005)

摘　　要：乳杆菌是世界上公认可食用的有益菌类,在维持肠道健康、促进机体免疫系统的发育与成熟等方面发挥重要作用。本文从乳杆菌在仔猪肠道中发挥的作用,被宿主细胞受体识别及介导的免疫调节信号机制,乳杆菌代谢产物乳酸、乳杆菌肽等发挥免疫调控作用的机理等方面系统综述了乳杆菌调控肠道黏膜免疫系统的作用机制,为畜牧生产上合理应用乳杆菌提供科学理论依据。Lactobacillus is known to be the edible bacterium and plays an important role in maintaining intestinal health,promoting the development and maturation of the immune system.This article summarized its functions and mechanism including the role of Lactobacillus in the intestine of piglets,the mutual recognition between Lactobacillus and the host cell receptor and their mediated immune regulation signal research,the metabolites such as lactic acid,Lactobacillus peptides exert immune regulation function.This reviewwould provide the scientific theory basis for reasonable application of Lactobacillus,and the reference for the clinical research and application of Lactobacillus.

关 键 词：乳杆菌 仔猪 肠道黏膜 免疫系统 作用机制 

分 类 号：S811.5[农业科学—畜牧学]