成人发病的散发性共济失调症临床诊疗  

Clinical Insights on Adult-onset Sporadic Ataxias

作　　者：张颖冬[1] 

机构地区：[1]南京医科大学附属南京医院神经内科,210006

出　　处：《中国临床神经科学》2015年第4期459-464,469,共7页Chinese Journal of Clinical Neurosciences

基　　金：国家自然科学基金(编号:81271418);江苏省六大人才高峰基金项目(编号:2012-WS0-86)

摘　　要：成人发病的散发性共济失调症是由多种原因所致,临床表现以共济失调为主要的多种疾病。致病原因包括中毒、免疫介导性、维生素缺乏、感染性疾病、变性病以及遗传性疾患等。散发性共济失调临床谱具有明显异质性,临床正确诊断极具挑战性。但相比于遗传性共济失调症,此类疾患多数治疗效果较好,及时、正确诊断尤为重要。现代生化、免疫以及影像学技术有助于此类疾患的认识和诊治。文中综述并讨论可致成人发病的散发性共济失调的不同疾病分类,并着重其临床和神经影像学表现及诊断标准。Adult-onset sporadic ataxias are a group of disorders manifested predominantly with ataxia, due to a variety of the potential causes including intoxication, immune-mediation, vitamins deficiencies, infections, neurodegeneration, and even some hereditary conditions. The clinical spectrum of these disorders is diverse, and their diagnosis remains a challenge. Compared with hereditary ataxias, most ataxias in this group respond the treatment well, that means the significance of timely and correct diagnosis. The advanced biochemical, immune and imaging tools will help the perception and management on those ataxias. Different categories of adult-onset sporadic ataxia were elucidated with the highlight on their clinical features, neuro-imagingand diagnostic criteria.

关 键 词：共济失调 成人发病 散发性 诊断 

分 类 号：R744.7[医药卫生—神经病学与精神病学]