靶向MTH1治疗肿瘤的研究进展  

Progress in treatment of cancer targeting MTH1

作　　者：沈颖[1] 沈培亮[1] 王旭[1] 王爱云[1] 陈文星[1] 郑仕中[1,2] 陆茵[1,2] 

机构地区：[1]南京中医药大学药学院 [2]江苏省中药药效与安全性评价重点实验室,江苏南京210046

出　　处：《中国药理学通报》2015年第9期1199-1201,共3页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金项目资助(No 81173174);教育部博士点基金(No 20113237110008);2013年江苏高校优秀科技创新团队计划

摘　　要：MTH1(mut T homolog1)是Mut T的同源酶,是一种核苷酸焦磷酸酶,主要参与DNA损伤修复过程,尤其在肿瘤细胞的DNA复制过程中发挥着重要角色。最新的研究表明,MTH1可以清除肿瘤细胞中受损DNA功能结构的氧化构件,使得肿瘤细胞继续分裂与增殖,从而维持肿瘤细胞的生存,而更为重要的是正常细胞不需要MTH1,因此,MTH1有可能只与异常的细胞生长密切相关,这使得MTH1作为治疗靶点成为人们关注的焦点。该文着重对MTH1与肿瘤关系最新的研究成果进行综述,探讨MTH1维持肿瘤生长的相关机制及其与肿瘤治疗的关系,为靶向MTH1治疗肿瘤提供新的思路,为肿瘤研究工作者提供重要参考。MTH1（ Mut T Homolog1） as Mut T homologous enzyme,is a nucleotide pyrophosphatase,mainly involved in DNA damage repair process,especially plays an important role in the process of DNA replication in tumor cells. Recent studies have found that MTH1＇s function is responsible for the development of a variety of tumors. Studies have shown that,MTH1 can remove tumor cells＇ oxidative DNA elements detrimental to the functional structure, protecting tumor cell division and proliferation,maintaining tumor cell survival,however,normal cells do not need MTH1. Therefore,MTH1 may be only closely associated with abnormal cell growth. This makes MTH1 as therapeutic targets that have been paid much attention. This article reviewed the relationship of MTH1 and tumor,discussed the mechanisms of MTH1 in tumor growth MTH1 and tumor treatment,so as to provide reference for clinical research and treatment of tumor.

关 键 词：MTH1 肿瘤 分子机制 DNA复制 氧化损伤 治疗策略 

分 类 号：R0-5[医药卫生] R342.3