大豆多糖辅助淫羊藿总黄酮喷雾干燥及其对粉体学性质的影响  

Study on totai flavonoids of Epimedium assisted with soybean polysaccharide spray-drying powder

作　　者：严红梅[1,2] 贾晓斌[1,2] 张振海[2] 孙娥[2] 邓佳慧[1] 

机构地区：[1]南京中医药大学,江苏南京210046 [2]江苏省中医药研究院国家中医药管理局中药释药系统重点研究室,江苏南京210028

出　　处：《中国中药杂志》2015年第15期2994-2998,共5页China Journal of Chinese Materia Medica

基　　金：苏州市科技发展计划医疗器械与新医药专项(ZXY2013022)

摘　　要：评价大豆多糖辅助淫羊藿总黄酮提取液喷雾干燥的特性。于淫羊藿总黄酮提取液中分别加入一定比例的大豆多糖进行喷雾干燥,观察大豆多糖对解决喷雾干燥粘壁效果的作用,同时考察淫羊藿总黄酮共喷雾干燥粉体的粉体学性质和有效成分的体外溶出行为。与淫羊藿总黄酮喷雾干燥粉体相比较,大豆多糖-淫羊藿总黄酮喷雾干燥粉体抗粘壁效果显著,粒径无明显变化,但粒子表面光滑,流动性提高,吸湿性改善,体外溶出度显著提高。大豆多糖在中药喷雾干燥粉体中的应用值得进一步研究和探索。In order to evaluate the characteristics of the spray drying of total flavonoids of Epimedium extracts assisted with soybean polysaccharide,a certain percentage of soybean polysaccharide or polyvidone were added to the total flavonoids of Epimedium extract to conduct the spray drying. The effect of soybean polysaccharides against the wall sticking effect of the spray drying was detected,as well as the powder property of total flavonoids of Epimedium spray drying powder and the dissolution in vitro behavior of the effective component. Compared with the total flavonoids of Epimedium spray drying powder,soybean polysaccharide revealed a significant anti-wall sticking effect. The spray drying power which had no notable change in the grain size made a increase in the fluidity,improvement in the moisture absorption and remarkable rise in the dissolution in vitro behavior. It was worth further studying the application of soybean polysaccharide in spray drying power of traditional Chinese medicine.

关 键 词：大豆多糖 喷雾干燥 流动性 吸湿性 溶出度 

分 类 号：R283.6[医药卫生—中药学]