肿瘤发生与相关基因突变的关联  

Association of Tumorigenesis with the Related Gene Mutation

作　　者：贺红娟[1] 陈尔飞[1] 雷蕾[1] 

机构地区：[1]西北大学生命科学学院,西安710069

出　　处：《基因组学与应用生物学》2015年第1期208-214,共7页Genomics and Applied Biology

基　　金：西北大学科研启动基金(批准号:PR13178)资助

摘　　要：肿瘤的发生常与其相关基因的突变有关,这些突变会引起编码基因的蛋白质的结构或数量的改变,从而导致其相关基因功能的丧失。突变在基因上发生的位置及类型的不同也会对基因的表达造成不同的影响。本文介绍了存在于肿瘤相关基因编码区及非编码区的突变与肿瘤发生发展的相互关系。本文还就肿瘤相关基因的突变类型阐述肿瘤的靶向治疗,提供了癌症治疗及预防的新思路。Tumorigenesis often associates with the mutations in its related genes.These gene mutations enable to change the structure and number of the encoding protein that might cause function loss.The difference in positions and types of mutations occurring in the gene results in the difference in gene expression.In this review,we introduced the relationship between tumorigenesis and the mutations of the related genes occurring in encoding and non-encoding region.We also proposed new ideas for cancer treatment and prevention through the targeted therapy based on the type of related gene mutations of tumor.

关 键 词：肿瘤发生 基因突变 编码区 非编码区 蛋白表达 

分 类 号：R730.231[医药卫生—肿瘤]