肾康注射液治疗慢性肾功能衰竭上市后监测的倾向指数研究  

Using Propensity Score to Assess the Efficacy of Shenkang Injection in Treating Chronic Renal Failure: Post-marketing Surveillance

作　　者：王永吉[1] 董成 叶楠 蔡宏伟[3] 李婵娟[1] 夏结来[1] 

机构地区：[1]第四军医大学预防医学院卫生统计学教研室,710032 [2]解放军第三O九医院医务部 [3]第四军医大学口腔医学院信息中心

出　　处：《中国卫生统计》2015年第4期589-590,共2页Chinese Journal of Health Statistics

基　　金：国家自然科学基金资助(30800952,81001290);解放军三○九医院院内课题

摘　　要：目的应用倾向指数方法,观察肾康注射液治疗慢性肾功能衰竭的疗效。方法随机选择2200例慢性肾功能衰竭患者接受治疗,注射肾康注射液,疗程4周。应用倾向指数匹配法后,剂量60 ml组和剂量100 ml组共665例患者,以中心作为随机效应,建立非线性混合效应模型进行疗效评估。结果在均衡了体重指数、病情分级等重要预后因素后,剂量60 ml和剂量100 ml组在慢性肾功能衰竭疗效方面差异无统计学意义。结论肾康注射液治疗慢性肾功能衰竭疗效确切,剂量60 ml和剂量100 ml疗效相当。Objective To verify the efficacy of Shenkang injection on patients with chronic renal failure. Methods 2200 patients with chronic renal failure were recruited and received Shenkang injection between the dosage of 60 ml and 100 ml once dally for 4 weeks： Using propensity score for dosage, we were able to match 665 patients with dosage of 60 ml or 100 ml. We constructed nonlinear mixed model regarding center as random effect to assess the efficacy. Results There is no significance difference between the dosage of 60 ml and 100 ml in the efficacy of chronic renal failure. Conclusion Shenkang injection is a valid treatment in chronic renal failure. The dosage of 60 ml is similar with the dosage of 100 ml in efficacy.

关 键 词：肾康注射液 慢性肾功能衰竭 倾向指数 非线性混合效应模型 

分 类 号：R277.5[医药卫生—中医学]