苯妥英钠的合成  

Synthesis of Sodium Phenytoin

作　　者：李公春[1] 吴长增[1] 郭俊伟[1] 孙婷[1] 牛亮峰 鞠志宇[1] 

机构地区：[1]许昌学院化学化工学院,河南许昌461000

出　　处：《浙江化工》2015年第8期23-25,共3页Zhejiang Chemical Industry

基　　金：河南省科技厅基础与前沿项目(142300410104);河南省高等教育教学改革项目(2014SJGLX319);河南省教育厅自然科学项目(14A150056)

摘　　要：由苯甲醛在维生素B1作催化剂及碱性条件下进行安息香缩合得到安息香,然后在酸性条件下用三氯化铁氧化安息香制取二苯乙二酮,二苯乙二酮与尿素在碱性条件下反应得到苯妥英,再由苯妥英与氢氧化钠反应成盐得到苯妥英钠。Benzoin was synthesized by benzaldehyde in alkaline condition under the catalysis of VB1. 1, 2-diphenyl ethanedione was prepared through oxidation of benzoin in acid condition using ferric chloride. 1, 2-diphenyl ethanedione reacted with urea via intramolecular cyclization reaction to obtain phenytoin. Sodium phenytoin was synthesized through reaction of phenytoin and sodium hydroxide.

关 键 词：苯妥英钠 二苯乙二酮 安息香 苯甲醛 合成 

分 类 号：O627.11[理学—有机化学] TQ463.5[理学—化学]