急性脑梗死患者OCSP分型与凝血指标变化相关性研究的临床意义  

Study on OCSP Classification of Acute Cerebral Infarction and Prothrombin Fragment 1＋2 and Antithrombin 3

作　　者：徐耀铭 齐晓飞[1] 吴占福[1] 张国锋[1] 李莹[1] 王姝姚 褚丽娜[1] 郑哲龙[1] 山花 

机构地区：[1]内蒙古自治区通辽市医院神经内二科,中国通辽028000

出　　处：《国际老年医学杂志》2015年第5期198-201,共4页International Journal of Geriatrics

摘　　要：目的：探讨急性脑梗死患者OCSP分型与凝血酶原片段1＋2和抗凝血酶3的相关性。方法：对入住我院神经内二科的64例患急性脑梗死患者进行OCSP分型，并选择门诊健康体检者作对照。应用酶联免疫吸附法（ ELISA）进行检测所有患者的血浆凝血酶原片段1＋2浓度和抗凝血酶3活性；分析两者与急性脑梗死OCSP分型的相关性。结果：急性脑梗死各亚型中，完全前循环性脑梗死（ TACI）、部分前循环性脑梗死（ PACI）和后循环性脑梗死（ POCI）患者血浆凝血酶原片段1＋2浓度明显高于腔隙性脑梗死（ LACI）和健康对照者，抗凝血酶3活性明显低于腔隙性脑梗死和健康对照者。结论：血浆凝血酶原片段1＋2浓度和抗凝血酶3活性的增高与TACI及PACI密切相关。OBJECTIVE： To explore the relationship between OCSP classification of acute cerebral infarction and prothrombin fragment 1＋2 and antithrombin 3. METHODS： 64 hospitalized patients with acute cerebral infarction were enrolled by OCSP classifi-cation. The health outpatients were control group. By the method of enzyme-linked immunosorbent （ ELISA） plasma prothrombin fragment 1＋2 concentration and antithrombin activity were tested. The relationship between OCSP classification of acute cerebral in-farction and both of two indexes was analysed. RESULTS： In cerebral infarction of completely before cycle （ TACI） , part of the cy-clical cerebral infarction （ PACI） before and after the circularity of patients with brain infarction （ POCI） plasma prothrombin fragment 1＋2 concentration was significantly higher than that of lacunar cerebral infarction （ LACI） and healthy control group. Antithrombin activity 3 was significantly lower than that of the lacunar cerebral infarction and healthy control group. CONCLUSION：Increasing plas-ma prothrombin fragment 1＋2 concentration and the three antithrombin activity are closely related to the TACI and PACI.

关 键 词：急性脑梗死 OCSP分型 凝血酶原片段1+2 抗凝血酶3 凝血改变 PROTHROMBIN fragment 1 +2 ANTITHROMBIN 3 

分 类 号：R743.33[医药卫生—神经病学与精神病学]