Glanzmann’s thrombasthenia(GT)is an inherited autosomal recessive bleeding disorder,resulting from mutations in the ITGA2B and ITGB3 genes,that lead to a defect in the platelet membrane integrinαIIbβ3.[1]As integri...
Supported by the National Natural Science Foundation of China,No.81670433 and No.81970398;the Project of Zhejiang Medical Young Talents(2017);Zhejiang Medical and Health Science and Technology Project,No.2020RC014;the Natural Science Foundation of Zhejiang Province,No.LR22H020002.
BACKGROUND Antithrombin Ⅲ(AT3)deficiency,an autosomal dominant disease,increases the likelihood of an individual developing venous thromboembolism(VTE).Longterm anticoagulation treatment is required for those sufferi...
Supported by the Affiliated Hospital of Guangdong Medical University,No.LCYJ2018C009.
BACKGROUND The hereditary antithrombin(AT)deficiency caused by SERPINC1 gene mutation is an autosomal dominant thrombotic disorder.An increasing number of studies have shown that mutations in the SERPINC1 rs2227589 po...
Background:To date,definitions of liver dysfunction(LD)after hepatic resection rely on late postoperative time points.Further,the used parameters are markedly influenced by perioperative management.Thus,we aimed to es...
AIM To determine potentially modifiable predictors of early outcomes after liver transplantation in children of age < 3 years.METHODS This study was a retrospective chart review including all consecutive children of a...
supported by the National Natural Science Foundation of China(No.91129706);NSFCShandong Joint Fund(No.U1406402);Taishan Scholar Special Fund of Shandong Province in China(L.Z.)
Cardiovascular disease is the leading causes of death.However,the complications can be treated with heparin and heparinoids,such as heparin pentasaccharide Fondaparinux,dermatan sulfate,and PSS made from alginate extr...
Disseminated intravascular coagulation(DIC) is a syndrome characterized by the systemic activation of blood clotting, which generates large amount of intravascular thrombin and fibrin. Various diseases may cause accel...
Antithrombin(AT) is a natural anticoagulant with antiinflammatory properties that has demonstrated value in sepsis, disseminated intravascular coagulation and in burn and inhalation injury. With high doses, AT maydecr...