乙醛脱氢酶2基因多态性和饮酒习惯与肝癌、胃癌、食管癌的易感性  

Polymorphisms of Aldehyde Dehydrogenase-2 Genotypes and Alcohol Consumption for the Susceptibility of the Liver Cancer,Stomach Cancer and Esophageal Cancer

作　　者：丁建华[1] 吴建中[1] 李苏平[1] 高长明[1] 周建农[1] 苏平[1] 刘燕婷[1] 周学富[2] 丁保国[2] 王如鸿 

机构地区：[1]江苏省肿瘤防治研究所流行病研究室,江苏南京210009 [2]泰兴市卫生防疫站,江苏泰兴225400

出　　处：《中国肿瘤》2002年第8期450-452,共3页China Cancer

基　　金：1999年江苏省社会发展基金重点项目资金资助(BS99026-1)

摘　　要：[目的]研究乙醛脱氢酶2(ALDH2)基因多态性和饮酒习惯与肝癌、胃癌和食管癌的易感性。[方法]88例肝癌以性别、年龄和居住地与对照按1∶1配对 ;104例胃癌和98例食管癌选择同一组(235例)非肿瘤居民为对照 ,用PCR RFLP方法检测研究对象的ALDH2基因型。[结果]肝癌、胃癌、食管癌病例与对照组中ALDH2变异基因型携带者分别占36.36%和35.23%、47.12%和45.36%、32.65%和45.36% ,差异无显著性。在携带ALDH2变异基因型的饮酒人中 ,每月饮酒总量>3kg者发生肝癌的危险性是≤3kg者的7.2倍 ,并存在显著的剂量效应关系。在携带ALDH2谷氨酸纯合型的男性中 ,饮酒者发生癌的危险性是不饮酒者的2.69倍。To study the relation between Aldehyde Dehydrogenase 2(ALDH2) genotypes and alcohol consumption for the susceptibility of liver cancer,stomach cancer,esophageal cancer. A case control study including 88 cases of newly diagnosed liver cancer and 88 controls matched on sex,age and resident area as well as 104 stomach cancer,98 esophageal cancer and 235 controls was carried out.Blood samples from all individuals were collected and tested for ALDH2 genotypes by PCR RFLP method. The frequencies of ALDH2 variant genotypes(ALDH21*2/ALDH22) in liver cancer,stomach cancer,esophageal cancer and their controls were 36.36% and 35.23%,47.12% and 45.36%,32.65% and 45.36% respectively.No difference was found between these two groups.The risk for liver cancer was 7.2 times in alcohol consumption >3kg/month comparing with that ≤3kg/month.It showed a close_related result.In male ALDH2 genotype carriers,the risk for gastric cancer was 2.69 times in alcohol consumers comparing with no alcohol consumers.[Conclusion] Our study revealed a strong relation between polymorphisms of ALDH2 genotypes and heavy alcohol consumption for susceptibility of liver cancer.

关 键 词：基因多态性 饮酒习惯 易感性 流行病学 乙醛脱氢酶2 ALDH2 肝肿瘤 胃肿瘤 食管肿瘤 

分 类 号：R73－31[医药卫生—肿瘤] R735[医药卫生—临床医学]