新生儿起病的克隆恩病1例报告  

One case report of neonatal onset Crohn disease

作　　者：刘晓景[1] 杨威[1] 陈永兴[1] 李春枝[1] 高静[1] 卫海燕[1] 周喜红[2] 

机构地区：[1]郑州市儿童医院内分泌遗传代谢科,河南郑州450052 [2]郑州市儿童医院消化内科,河南郑州450052

出　　处：《临床儿科杂志》2015年第9期776-778,共3页Journal of Clinical Pediatrics

摘　　要：目的探讨新生儿起病的克隆恩病的诊断和治疗。方法回顾性分析1例新生儿起病的克隆恩病患儿的临床资料。结果男性患儿,生后5 d即出现间断发热、口腔溃疡、皮肤脓疱疹、间断腹泻伴白细胞增高,先后诊断为"脓毒血症、细菌性肠炎、白塞病、免疫缺陷病、营养性贫血、牛奶不耐受、炎症性肠病",直肠黏膜病理诊断及术后肠管病理检查确诊为克隆恩病,于8月龄死于肠穿孔。结论对于新生儿起反复口腔溃疡、皮肤脓疱疹、肛周溃疡和发热的患儿,应及早进行结肠镜检查以明确诊断。ObjectiveTo investigate the diagnosis and treatment of Crohn disease in neonates.Methods The clinical data of one case of neonatal onset Crohn disease were retrospectively analyzed.Results Male infant had intermittent fever, recurrent oral ulcers, skin impetigo and intermittent diarrhea with increased WBC counts from ifve days after birth. He had been diagnosed as sepsis, bacterial enteritis, Behcet＇s disease, immunodeifciency disease, nutritional anemia, milk intolerance, and inlfammatory bowel disease. Finally he was diagnosed as Crohn disease by rectal mucosa pathology and postoperative bowel pa-thology. He died of intestinal perforation on 8 months.ConclusionsThe infants who have recurrent oral ulcers, skin impetigo, perianal ulcers and fever from neonatal should undergo colonoscopy for the diagnosis.

关 键 词：炎症性肠病 克隆恩病 溃疡性结肠炎 诊断 新生儿 

分 类 号：R722.1[医药卫生—儿科]