子宫肌瘤并发淀粉样变患者发病机制研究  

Studies on pathogenesis in patients with uterine leiomyoma complicated by amyloidosis

作　　者：郭丽香[1] 王亮[2] 罗跃娥[1] 李晓亮[2] 刘晓春[2] 黄珊[2] 孙续国[2] 

机构地区：[1]天津医学高等专科学校,300222 [2]天津医科大学检验学院

出　　处：《天津医药》2015年第9期1006-1008,I0005,共4页Tianjin Medical Journal

摘　　要：目的探讨子宫肌瘤并发淀粉样变患者发病机制。方法子宫肌瘤患者36例。依据组织病理刚果红(CR)染色结果分为淀粉样变组6例和非淀粉样变组30例。(1)观察淀粉样变组淀粉样变沉积部位。(2)HE染色比较2组炎性细胞浸润情况。(3)PAS染色观察淀粉样变组多糖类物质沉积的变化。(4)比较2组血红蛋白(HGB)、白细胞计数(WBC)、淋巴细胞绝对值(LYM)、中性粒细胞绝对值(NEU)、总蛋白(TP)、白蛋白(Alb)及前白蛋白(PA)的含量。结果 (1)肌瘤实体纤维细胞间质未见淀粉样变,而肌瘤周围的假被膜纤维区(5/6)及假被膜血管壁(2/6)淀粉样沉积发生率高。(2)2组均可见炎性细胞浸润。(3)淀粉样变沉积阳性及阴性部位均可见PAS阳性。(4)2组HGB、WBC、NEU、LYM、TP、Alb和PA水平差异均无统计学意义(P>0.05)。结论子宫肌瘤纤维细胞功能改变引起局部组织细胞代谢微环境的变化可能与淀粉样变形成有关。Objective To investigate the pathogenesis in patients with uterine leiomyoma complicated by amyloidosis. Methods A total of 36 uterine leiomyoma patients were recruited in this study, and divided into two group by Congo red staining：amyloidosis group （n=6） and non-amyloidosis group （n=30）. （1） Amyloidosis deposition was observed in amyloidosis group. （2） HE staining was used to compare changes of inflammatory cells in two groups. （3）PAS staining was used to observe polysaccharide difference in two groups. （4）Values of serum hemoglobin （HGB）, white blood cell count （WBC）, lymphocyte absolute value （LYM）, neutrophil absolute value （NEU）, total protein （TP）, albumin （Alb） and prealbumin （PA） were compared between two groups. Results （1）Leiomyoma entity cells were negatively Congo red stained, while 5 out of 6 pseudo-capsule fiber deposition and 2 out of 6 blood vessel were positively Congo red stained. （2）Infiltrations of inflammatory cells were observed in two groups. （3） The PAS positive staining was found in amyloidosis deposition and non-amyloidosis deposition groups. （4）There were no significant differences in HGB, WBC, NEU, LYM, TP, Alb and PA levels between two groups （P〉0.05）. Conclusion Metabolism changes resulted from cell function alterations in local micro-environment by uterine leiomyoma may be related to the formation of the amyloidosis.

关 键 词：淀粉样变性 子宫肌层 平滑肌瘤 发病机制 子宫肌瘤 

分 类 号：R737.33[医药卫生—肿瘤]