长链非编码RNA与宫颈癌  

Long Noncoding RNA and Cervical Cancer

作　　者：李淑娟[1] 唐一通[2] 

机构地区：[1]延安大学西安创新学院,西安710100 [2]湖北文理学院,襄阳441053

出　　处：《中国细胞生物学学报》2015年第9期1317-1322,共6页Chinese Journal of Cell Biology

摘　　要：长链非编码RNA(long noncoding RNA,lnc RNA)是一类长度超过200个核苷酸、无蛋白编码功能的一类RNA分子。Lnc RNA在人类肿瘤发生中发挥着重要作用,可在表观遗传学、转录及转录后水平调控基因表达,影响肿瘤的发生、发展,并且与肿瘤侵袭、转移及患者预后有一定关系。近年研究表明,lnc RNA在宫颈癌中异常表达,发挥着癌基因或抑癌基因活性,可成为宫颈癌分子诊断和基因治疗的新靶点。该文就lnc RNA在宫颈癌中的最新研究进展作一综述。Long noncoding RNAs （lncRNAs） are greater than 200 nucleotides in length with non-protein coding transcripts. LncRNAs play an important role in human carcinogenesis. They regulate the expression of genes at the epigenetic, transcriptional and post-transcriptional levels and are associated with the occurrence, development, invasion, metastasis and prognosis of tumors. Recent studies show that lncRNAs have been expressed abnormally in cervical cancer, playing oncogenic or tumor suppressive activity. They may become new targets for molecular diagnosis and gene therapy of cervical cancer. In this paper, the latest research and progress of lncRNA in cervical cancer are reviewed.

关 键 词：长链非编码RNA 作用机制 宫颈癌 基因表达 

分 类 号：R737.33[医药卫生—肿瘤]