线粒体基因突变与糖尿病的相关性研究综述  

The Research Summarizes on the Correlation of Mitochondrial Gene Mutation and Diabetes

作　　者：李晓明[1,2] 杨莹[1,2] 彭辉[2] 刘永莹[2] 龙钦鹏 

机构地区：[1]大理大学临床医学院,云南大理671000 [2]云南省第二人民医院内分泌与代谢病科,云南昆明650021

出　　处：《现代生物医学进展》2015年第25期4993-4996,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81260135)

摘　　要：糖尿病是以出现慢性高血糖为特征的。遗传因素在出现这种紊乱中可能占有重要角色。有研究表明核基因突变对胰岛素的分泌有影响,此外,在有些家庭中,糖尿病出现母系遗传,很可能是因为线粒体基因突变导致母系遗传。事实上,线粒体基因可能可以导致糖尿病,因为线粒体的氧化磷酸化在β细胞中血糖刺激胰岛素的分泌占有重要作用。已有大量研究表明线粒体基因突变与糖尿病的发病有关,在糖尿病患者的线粒体基因中发现大量的新发突变体,并且证实这些新发突变与糖尿病以及糖尿病并发症的发病有相关性。本文主要综述国内外近五年有关线粒体基因突变与糖尿病相关性的研究论文,从而探索线粒体基因突变与糖尿病的相关性,为糖尿病的发病机制提供新的见解。Diabetes mellitus（DM） is a heterogeneous disorder characterized by the presence of chronic hyperglycemia. Genetic factors play an important role in the development of this disorder, and several studies reported mutations in nuclear genes implicated in the insulin function. Besides, DM can be maternally transmitted in some families, possibly due to the maternal mitochondrial inheritance.In fact, mitochondrial genes may be plausible causative agents for diabetes, since mitochondrial oxidative phosphorylation plays an important role in glucosestimulated insulin secretion from beta cells. A large number of studies have shown that mitochondrial gene mutation is correlated with the onset of Diabetes mellitus. They found a lot of new mitochondrial genes mutants in diabetes patients, And confirmed that these new mutations have correlation with the onset of diabetes and diabetic complications. This article mainly reviewed about mitochondrial gene mutation and diabetes correlation research paper nearly five years at home and abroad, To explore the correlation of mitochondrial gene mutation and diabetes. Provide new insight into the pathogenesis of diabetes.

关 键 词：线粒体 基因突变 糖尿病 

分 类 号：R394.3[医药卫生—医学遗传学]