青蒿素类化合物抗肿瘤研究新进展  

New progresses on the antitumor research of artemisinin-derived compounds

作　　者：袁亚[1] 李晓光[1] 巴乾[1] 王慧[1] 

机构地区：[1]中国科学院上海生命科学研究院营养科学研究所,中国科学院食品安全重点实验室(筹),上海200031

出　　处：《生命科学》2015年第9期1181-1192,共12页Chinese Bulletin of Life Sciences

基　　金：国家杰出青年科学基金项目(81125020);上海市科技支撑项目(12431900500)

摘　　要：传统中药及其天然活性成分为现代医药发展提供了丰富的资源。青蒿素及其衍生物的抗疟活性已得到世界公认,具有起效快、药效高、毒副作用低等优点。不断深入的研究揭示了该类化合物具有良好的抗肿瘤作用,如诱导细胞周期阻滞、促进细胞凋亡、抑制肿瘤血管生成、阻断肿瘤细胞的侵袭转移等。目前,在认识青蒿素类化合物抗癌分子作用机理的基础上对其进行结构改造,为新型一类抗肿瘤药物的研制奠定基础。对青蒿素及其衍生物的抗肿瘤活性及相关分子机制研究现状进行了综述。Traditional Chinese medicine and related natural active ingredients provide rich resources for the development of modem medicine. The antimalarial activities of artemisinin and its derivatives have been widely acknowledged around the world, because of its quick effect, high efficacy and low toxicity. As research continues, artemisinin has been demonstrated to have cytotoxic effects against a variety of cancer cells through inducing cell cycle arrest, promoting apoptosis, preventing angiogenesis, and abrogating cancer metastasis, etc. Great progresses have been achieved on anti-tumor mechanisms of artemisinin compounds and these were systematically reviewed here, which may provide sights for novel anticancer agents development in the future.

关 键 词：青蒿素 青蒿素衍生物 肿瘤 分子机制 

分 类 号：R730.5[医药卫生—肿瘤] R927.2[医药卫生—临床医学]