木耳提取物喷雾干燥工艺考察  

Investigation on Spray Drying Technology of Auricularia auricular Extract

作　　者：周蓉[1] 陈卉[1] 谢媛[1] 陈朋[1] 王洛临[1,2] 

机构地区：[1]广州中医药大学,广东广州510105 [2]广东省中医药工程技术研究院/广东省中医药研究开发重点实验室,广东广州510095

出　　处：《中药材》2015年第7期1509-1512,共4页Journal of Chinese Medicinal Materials

摘　　要：目的:考察木耳提取物喷雾干燥的可行性及其最佳工艺。方法:在单因素试验的基础上,采用正交试验法,以干燥物得率和多糖含量为指标,对影响干燥效果的进风温度、进样速度和浓缩液生药含量进行优选。并采用紫外分光光度法、薄层色谱法和药效学指标,比较传统醇沉真空干燥工艺与喷雾干燥工艺制备的提取物的区别。结果:木耳提取物采用喷雾干燥法,最佳工艺条件为:进风温度180℃,进样速度10 m L/min,生药含量为0.4 g/m L。与传统制备方法比较,所得提取物在多糖含量、薄层色谱图和降TG、TC作用无差异。结论:木耳提取物采用喷雾干燥法稳定可行,且经济效益高。Objective： To investigate the feasibility of spray drying technology of Auricularia auricular extract and its optimum process. Methods： On the basis of single factor test,with the yield of dry extract and the content of polysaccharide as indexes,orthogonal test method was used to optimize the spray drying technology on the inlet air temperature,injection speed and crude drug content. Using ultraviolet spectrophotometry,thin layer chromatography（ TLC） and pharmacodynamics as indicators,extracts prepared by traditional alcohol precipitation drying process and spray drying process were compared. Results： Compared with the traditional preparation method,the extract prepared by spray drying had little differences from the polysaccharide content,TLC and the function of reducing TG and TC,and its optimum technology condition were as follows： The inlet air temperature was 180 ℃,injection speed was 10 m L / min and crude drugs content was 0. 4 g / m L. Conclusion： Auricularia auricular extract by spray drying technology is stable and feasible with high economic benefit.

关 键 词：木耳 喷雾干燥 真空干燥 薄层色谱 药效学 

分 类 号：R286.2[医药卫生—中药学]