进食及进水早期降低对Fibroscan实施受控衰减参数的短期影响  

Food or water intake transiently decreases controlled attenuation parameters values

作　　者：傅玉娟[1] 祁婷婷[1] 熊鸣[1] 李小溪[2] 李晨钟[3] 王月刚[4] 王媛媛[2] 邓红[5] 关阳[6] 冯媛[7] 杨淑玲[1] 秦建增[8] 陈金军[1] 戴萌[2] 侯金林[1] 

机构地区：[1]南方医科大学南方医院感染内科,广州510515 [2]南方医科大学南方医院健康管理中心,广州510515 [3]南方医科大学南方医院内分泌与代谢科,广州510515 [4]南方医科大学南方医院心血管内科,广州510515 [5]南方医科大学公共卫生与热带医学学院 [6]南方医科大学营养科 [7]南方医科大学呼吸睡眠中心 [8]南方医科大学中医药学院

出　　处：《肝脏》2015年第7期517-521,共5页Chinese Hepatology

基　　金：国家自然科学基金(81270533,81470038);"863"课题(2012AA022605);教育部博士点专项课题(20124433120016)

摘　　要：目的评价进食及进水对FibroScan○R实施受控衰减参数(CAP)的影响。方法使用FibroScan○R502机型对健康人、非酒精性脂肪肝患者进行CAP测定。进食方案:全流质早餐(600 kcal,600 mL温水配制),10 min内进食完毕;进水方案:600 mL水,5 min内饮用完毕,进食或进水后多个时间点检测CAP值(dB/m)。结果进食前CAP值(200.4±13.2)dB/m,7例受试者进食后30 min CAP(191.6±12.3)dB/m,变化不明显(P=0.148),进食后60 min(187.6±8.7)dB/m,下降明显(P=0.029);另受试者(n=25)进食后120 min(193.9±31.0)dB/m或240 min(194.7±32.4)dB/m的CAP值与进食前(196.8±33.7)dB/m相比变化不显著(均P>0.05)。无脂肪肝受试者(n=20)空腹CAP值为(195.5±24.3)dB/m,进水后15 min(177.7±31.0)dB/m和30 min(176.7±25.2)dB/m下降明显(均P<0.01),60 min时CAP值(191.3±24.9)dB/m,与空腹无差异(P=0.197)。非酒精性脂肪肝患者(n=22)空腹CAP值为(298.1±43.6)dB/m,进水后15 min(274.9±41.8)dB/m和30 min(271.9±42.4)dB/m明显下降(均P<0.01),60 min(293.6±42.1,P=0.165)与空腹无差异。空白对照10例健康受试者在15 min(191.5±44.4)、30 min(190.9±45.4)dB/m及60 min(189.9±43.9)dB/m的CAP值与0时(189.4±50.3)dB/m均无差异(均P>0.05)。结论进食或进水使得CAP检测值短时下降。禁食禁水或进食2 h、进水1 h后检测可以提高CAP检测值的一致性。Objective To estimate the effects of food or water intake on controlled attenuation parameters（CAP）measurements with FibroScan502.Methods Transient elastographies（TEs）were performed on both healthy volunteers and non-alcoholic fatty liver（NAFL）patients with FibroScan502 at baseline（fasting,T0）,30 minutes（T30）,60 minutes（T60）,120minutes（T120）and 240minutes（T240）after intake of a standardized breakfast（600mL,600 kcal,19.4%protein,54.4% carbohydrates,26.2% fat）,respectively.CAP measurements were also performed at baseline（fasting,T0）,15minutes（T15）,30minutes（T30）and 60minutes（T60）after water drinking（600 mL）,respectively.Healthy individuals who volunteered to receive repeated TEs at variable time points without taking food or water were regarded as fasting controls.Results Compared with CAP values at T0（200.4±13.2 dB/m）,there were no significant changes at T30（191.6±12.3 dB/m,P=0.148）,while there were significant reductions at T60（187.6±8.7 dB/m,P=0.029）in seven healthy individuals taking standardized breakfast.There were no significant changes in CAP values at T120（193.9±31.0dB/m,P=0.619）or T240（194.7±32.4 dB/m,P=0.645）compared with that at T0（196.8±33.7dB/m）in another 25 individuals taking food.Significant decreases in CAP values were observed in 20 healthy volunteers drinking 600 mL water at T15（177.7±31.0dB/m,P=0.001）and T30（176.7±25.2 dB/m,P0.001）compared with T0（195.5±24.3 dB/m）,while there were no significant differences at T60（191.3±24.9 dB/m,P=0.197）.Consistently,CAP values at T15（274.9±41.8 dB/m,P0.001）and T30（271.9±42.4 dB/m,P0.001）of 22 non-alcoholic fatty liver individuals were significantly lower than that at T0（298.1±43.6 dB/m）,while T60 values（293.6±42.1 dB/m,P=0.165）rebounded to baseline value.As for the 10 volunteers without water or food intake,compared with baseline CAP values（189.4±50.3 dB/m）,there were no significant differences in CAP values at T15（191.5±4

关 键 词：瞬时弹性扫描 受控衰减参数 非酒精性脂肪肝 

分 类 号：R575.5[医药卫生—消化系统]