NPY和GAL在癫痫持续状态患儿治疗前后水平变化的分析  

Changes of pre-and post-treatment NPY and GAL levels in children with status epilepticus

作　　者：黄月艳[1] 潘红飞[1] 李强[1] 李清锋[1] 黄云峰[1] 黄致敬 唐汉庆[1] 钟京梓[1] 

机构地区：[1]右江民族医学院附属医院,广西百色533000

出　　处：《右江民族医学院学报》2015年第5期667-669,共3页Journal of Youjiang Medical University for Nationalities

基　　金：广西卫生厅课题(Z2008475);广西百色市科技局课题(百科计字[2008]11号)

摘　　要：目的探讨癫痫持续状态(status epilepticus,SE)患儿治疗前后血浆神经肽Y(neuropeptide Y,NPY)和甘丙肽(galanin,GAL)水平变化及临床意义。方法 SE患儿42例作为治疗组,40例健康儿童作为对照组。治疗组给予常规治疗并联用丙戊酸钠。治疗组和对照组在治疗前后测定血浆NPY和GAL水平。结果和对照组比较,治疗组治疗前NPY和GAL水平较低,差异均有统计学意义(P<0.001);治疗组治疗后,NPY和GAL水平均升高,和对照组比较,差异均有统计学意义(P<0.001)。结论 NPY和GAL具有抗癫痫作用,提示丙戊酸钠可能通过NPY和GAL起效。Objective This article studies on changes and clinical significance of neuropeptide Y （NPY） and galanin （GAL）in children with status epilepticus （SE）before and after treatment. Methods Forty-two children with SE were allocated to a treatment group while 40 healthy children as a control group.The treat-ment group was given conventional therapy combined with sodium valproate.All the levels of plasma NPY and GAL were measured before and after treatment for both groups. Results Compared with the control group, the pre - treatment NPY and GAL in the treatment group decreased and there was statistically significant difference （P 〈0.001）.After treatment in the treatment group both the levels of NPY and GAL elevated,and compared with the control group,there was statistically significant difference （P 〈0.001）. Conclusion So-dium valproate might take an effect in the treatment of SE by the way of anti - epileptic effect of NPY and GAL.

关 键 词：神经肽Y 甘丙肽 癫痫持续状态 

分 类 号：R742.1[医药卫生—神经病学与精神病学]