一类生物过程的稳态优化  

Steady-State Optimization for a Class of Biological Process

作　　者：高群王 徐恭贤[1] 王佳星[1] 

机构地区：[1]渤海大学数理学院,辽宁锦州121013

出　　处：《重庆理工大学学报（自然科学）》2015年第10期152-158,共7页Journal of Chongqing University of Technology：Natural Science

基　　金：国家自然科学基金资助项目(11101051;11371071);辽宁省高等学校优秀人才支持计划项目(LJQ2013115);辽宁省自然科学基金资助项目;辽宁省大学生创新创业训练计划项目(201510167000012)

摘　　要：研究了甘油生物歧化为1,3-丙二醇过程的稳态优化。针对甘油生物歧化为1,3-丙二醇过程的还原途径酶催化非线性动力系统,首先提出了一个使1,3-丙二醇产率达到最大的稳态优化模型,然后应用内点法对其进行求解,最后获得了甘油生物歧化为1,3-丙二醇过程的最优操作条件及1,3-丙二醇的最大产率。Steady-state optimization for continuous bio-dissimilation process of glycerol to 1,3-propanediol was addressed. According to a nonlinear dynamic system of enzyme-catalytic kinetics on the bioprocess,a steady-state optimization model was first proposed. This problem maximized the production rate of 1,3-propanediol. Then the interior point method was used for solving the proposed optimization problem. Finally,the optimal operation condition for continuous bio-dissimilation process of glycerol to 1,3-propanediol was obtained. The maximum rate of 1,3-propanediol production was also attained.

关 键 词：生物过程 1 3-丙二醇 稳态优化 最优操作 内点法 

分 类 号：O29[理学—应用数学]