19例Gilbert综合征临床分析  

Clinical analysis of 19 cases of Gilbert syndrome

作　　者：何煊[1] 罗珠林[1] 汤善宏[1] 王钊[1] 曾建梅[1] 曾维政[1] 徐辉[1] 蒋明德[1] 

机构地区：[1]成都军区总医院消化内科,成都610083

出　　处：《中国中西医结合消化杂志》2015年第10期682-683,共2页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

摘　　要：[目的]提高对Gilbert综合征临床诊断水平。[方法]回顾性分析我院收治、确诊的19例Gilbert综合征患者资料。[结果]19例高胆红素血症患者均以间接胆红素升高为主（24.7-157.4μmol/L）,直接胆红素轻度升高（7.9-23.5μmol/L）,少数患者,直接胆红素正常。患者绝大多数是青年男性。黄疸出现的年龄,多数为青少年。黄疸是主要临床表现。所有病例,经过肝脏穿刺病理检查,肝脏组织结构基本正常,确诊Gilbert综合征。所有病例的血常规、肝脏的酶学、肝炎的病原学、自身免疫性肝炎的抗体、腹部B超等检查,全部正常。[结论]Gilbert综合征是临床少见的先天性黄疸。临床表现为慢性、非溶血性、间接胆红素增高为主的高胆红素血症,预后良好。[Objective]To improve the clinical diagnosis of Gilbert syndrome. [Methods]19 cases of Gilbert syndrome in our hospital were retrospectively analyzed. [Results] 19 cases of hyperbilirubinemia pa- tients showed an indirect bilirnbin increase mainly（24.7μmol/L-157.4μmol/L）, direct bilirubin increase slightly（7.9μmol/L-23.5μmol/L）. A few patients showed normal direct bilirubin. The vast majority of patients were young males. The majority age of jaundice was young and juvenile. Jaundice was the main clinical manifestation. All cases were confirmed as Gilbert syndrome with the normal liver structure with liver biopsy and pathological examination. Blood routine, liver enzymology, etiology of hepatitis, autoim- mune hepatitis antibody,and abdominal ultrasound examination of all the cases were normal. [Conclusion] Gilbert syndrome is a rare congenital jaundice, mainly manifested as chronic,non hemolytic high blood bilirubin,indirect bilirubin increase with good prognosis.

关 键 词：GILBERT综合征 间接胆红素 肝脏穿刺 病理检查 临床分析 

分 类 号：R57[医药卫生—消化系统]