The association between metabolic syndrome and advanced prostate cancer in Chinese patients receiving radical prostatectomy  

代谢综合征与根治性前列腺切除术患者进展性前列腺癌的相关性

作　　者：Gui-Ming Zhang Yao Zhu Da-Hai Dong Cheng-Tao Han Cheng-Yuan Gu Wei-Jie Gu Xiao-Jian Qin Li-Jiang Sun Ding-Wei Ye 

机构地区：[1]Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China [2]Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China [3]Department of Urology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China

出　　处：《Asian Journal of Andrology》2015年第5期839-844,I0011,共7页亚洲男性学杂志（英文版）

基　　金：This study was supported in part by grant from the National Natural Science Foundation of China （No. 81272837）.

摘　　要：The global incidence of metabolic syndrome （MetS） is dramatically increasing. Considerable interest has been devoted to the relationship between MetS and prostate cancer （PCa） risk. However, few studies have examined the association between MetS and PCa progression. This retrospective study consisted of 1016 patients with PCa who received radical prostatectomy. The association between MetS and pathological features was evaluated using logistic regression analysis. Compared with patients without MetS, those with MetS indicated an increased risk of prostatectomy Gleason score （GS）≥8 （odds ratio [OR] =1.670, 95% confidence interval （CI） 1.096-2.545, P = 0.017）, and a 1.5-fold increased risk of pT3-4 disease （OR = 1.583, 95% CI 1.106-2.266, P = 0.012）. The presence of MetS was an independent predictor of lymph node involvement （OR = 1.751, 95% CI 1.038-2.955, P = 0.036）. Furthermore, as the number of MetS components accumulated, the risk of a GS ≥ 8 increased. The present study indicates a significant association between MetS and advanced PCa. The results need to be evaluated in large-scale prospective cohorts.The global incidence of metabolic syndrome （MetS） is dramatically increasing. Considerable interest has been devoted to the relationship between MetS and prostate cancer （PCa） risk. However, few studies have examined the association between MetS and PCa progression. This retrospective study consisted of 1016 patients with PCa who received radical prostatectomy. The association between MetS and pathological features was evaluated using logistic regression analysis. Compared with patients without MetS, those with MetS indicated an increased risk of prostatectomy Gleason score （GS）≥8 （odds ratio [OR] =1.670, 95% confidence interval （CI） 1.096-2.545, P = 0.017）, and a 1.5-fold increased risk of pT3-4 disease （OR = 1.583, 95% CI 1.106-2.266, P = 0.012）. The presence of MetS was an independent predictor of lymph node involvement （OR = 1.751, 95% CI 1.038-2.955, P = 0.036）. Furthermore, as the number of MetS components accumulated, the risk of a GS ≥ 8 increased. The present study indicates a significant association between MetS and advanced PCa. The results need to be evaluated in large-scale prospective cohorts.

关 键 词：Gleason score metabolic syndrome PATHOLOGY prostate cancer 

分 类 号：R[医药卫生]