Functional states of resident vascular stem cells and vascular remodeling  

作　　者：Desiree F. Leach Mitzi Nagarkatti Prakash Nagarkatti Taixing Cui 

机构地区：[1]Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29209, USA [2]Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC 29209, USA

出　　处：《Frontiers in Biology》2015年第5期387-397,共11页生物学前沿（英文版）

摘　　要：Recent evidence indicates that different types of vascular stem cells （VSCs） reside within the mural layers of arteries and veins. The precise identities of these resident VSCs are still unclear; generally, postnatal vasculature contains multilineage stem cells and vascular cell lineage-specific progenitor/stem cells which may participate in both vascular repair and lesion formation. However, the underlying mechanism remains poorly understood. In this review, we summarize the potential molecular mechanisms, which may control the quiescence and activation of resident VSCs and highlight a notion that the differential states of resident VSCs are directly linked to vascular repair or lesion formation.Recent evidence indicates that different types of vascular stem cells （VSCs） reside within the mural layers of arteries and veins. The precise identities of these resident VSCs are still unclear; generally, postnatal vasculature contains multilineage stem cells and vascular cell lineage-specific progenitor/stem cells which may participate in both vascular repair and lesion formation. However, the underlying mechanism remains poorly understood. In this review, we summarize the potential molecular mechanisms, which may control the quiescence and activation of resident VSCs and highlight a notion that the differential states of resident VSCs are directly linked to vascular repair or lesion formation.

关 键 词：vascular stem cell QUIESCENCE ACTIVATION REMODELING 

分 类 号：Q463[生物学—生理学] Q813