天然产物中α-葡萄糖苷酶抑制剂的研究进展  

Advancement in research of α-glucosidase inhibitors of natural products

作　　者：于彩云[1] 高兆兰[1] 陈天姿 魏涛[1] 

机构地区：[1]北京联合大学应用文理学院,生物活性物质与功能食品北京市重点实验室,北京100191

出　　处：《食品工业科技》2015年第22期394-399,共6页Science and Technology of Food Industry

基　　金：北京联合大学生物活性物质与功能食品北京市重点实验室开放课题(ZK70201405);北京联合大学“启明星”大学生科技创新项目(201511417SJ081)

摘　　要：α-葡萄糖苷酶抑制剂能够有效降低餐后血糖,是II型糖尿病的首选药物。目前,已有三种上市药物。本文主要对已上市α-葡萄糖苷酶抑制剂药物、天然产物中发现的各类α-葡萄糖苷酶抑制剂,如多糖类、类黄酮类、糖苷类、生物碱类、萜类、有机酸类、醇类、酯类和蛋白类抑制剂及其筛选模型进行综述,以期为α-葡萄糖苷酶抑制剂的筛选、研究和应用提供借鉴。The α-glucosidase inhibitors are effectively reduce postprandial blood glucose,which is the first choice on treatment of type II diabetes. At present,there have been three kinds of drugs in market. This paper mainly reviews three listed drugs,all kinds of α-glucosidase inhibitors discover from the natural products and screening model in recent years. It is expected to provide references for α-glucosidase inhibitors of screening,research and application.

关 键 词：糖尿病 Α-葡萄糖苷酶抑制剂 天然产物 筛选技术 

分 类 号：TS201.1[轻工技术与工程—食品科学]