虾青素胶囊对高脂血症人群降血脂功能研究  

Hypolipidemic effect of astaxanthin capsule in hyperlipidemia population

作　　者：陈东方[1] 王海玉[1] 张聪恪[1] 李立[1] 张焱[1] 

机构地区：[1]河南省疾病预防控制中心毒理室,河南郑州450016

出　　处：《实用预防医学》2015年第12期1435-1437,共3页Practical Preventive Medicine

基　　金：河南省基础与前沿技术计划项目(142300410344)

摘　　要：目的探讨虾青素胶囊对高脂血症人群辅助降血脂作用。方法将110例高脂血症者按血脂水平随机分为受试组和对照组,受试组连续服用虾青素胶囊45d,对照组服用相同外观的安慰剂。服用前后测定血清中总胆固醇(TC)、甘油三酯(TG)和高密度脂蛋白胆固醇(HDL-C)水平和安全性指标。结果试食后受试组TC水平明显下降,下降率为13.04%,自身前后比较及与对照组比较差异有统计学意义(P<0.01);TG水平明显下降,下降率为16.75%,自身前后比较及与对照组比较差异有统计学意义(P<0.05);HDL-C水平无明显变化。各项安全性指标试验前后均无明显改变。结论虾青素胶囊对高脂血症人群具有辅助降血脂作用。Objective To explore the hypolipidemie effect of astaxanthin capsule in hyperlipidemia population. Methods One hundred and ten hyperlipidemia volunteers were randomly divided into the test group and the control group according to their serum lipid levels. The volunteers in the test group were orally administered with astaxanthin capsule for 45 successive days, while thcxse in the control group took placebo with the same exterior. Serum. total cholesterol （TC）, triglyceride （TG） and high density lipoprotein cholesterol （HI）L - C） and the indexes of safety were determined before and after administration. Results After medication for 45 days, the serum levels of TC and TG in the test group were significantly lower than those in the control group （ P 〈 0.05 or P 〈 0.01 ）, and decreased by 13.04 % and 16.75 % respectively when compared with the levels before administra- tion , with statistical significance （P〈0.01） . The level of HDL- C and all indexes of safety did not change significantly.

关 键 词：虾青素胶囊 高脂血症 降血脂 人体试验 

分 类 号：R155.1[医药卫生—营养与食品卫生学]