Cancer therapy using natural ligands that target estrogen receptor beta  

作　　者：Gangadhara R Sareddy Ratna K.Vadlamudi 

机构地区：[1]Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio [2]Cancer Therapy & Research Center, University of Texas Health Science Center at San Antonio

出　　处：《Chinese Journal of Natural Medicines》2015年第11期801-807,共7页中国天然药物（英文版）

基　　金：supported by the NIH/NCI grant CA178499-01(RKV);CPRIT Training grant RP140105(GRS);2014-15 ABTA Discovery grant(GRS)

摘　　要：Estrogen receptor beta(ERβ) is one of the two key receptors(ERα, ERβ) that facilitate biological actions of 17β-estradiol(E2). ERβ is widely expressed in many tissues, and its expression is reduced or lost during progression of many tumors. ERβ facilitates estrogen signaling by both genomic(classical and non-classical) and extra-nuclear signaling. Emerging evidence suggests that ERβ functions as a tissue-specific tumor suppressor with anti-proliferative actions. Recent studies have identified a number of naturally available selective ERβ agonists. Targeting ERβ using its naturally available ligands is an attractive approach for treating and preventing cancers. This review presents the beneficial actions of ERβ signaling and clinical utility of several natural ERβ ligands as potential cancer therapy.Estrogen receptor beta （ERβ） is one of the two key receptors （ERα, ERβ） that facilitate biological actions of 17β-estradiol （E2）. ERβ is widely expressed in many tissues, and its expression is reduced or lost during progression of many tumors. ERβ facilitates estrogen signaling by both genomic （classical and non-classical） and extra-nuclear signaling. Emerging evidence suggests that ERβ functions as a tissue-specific tumor suppressor with anti-proliferative actions. Recent studies have identified a number of naturally available selective ERβ agonists. Targeting ERβ using its naturally available ligands is an attractive approach for treating and preventing cancers. This review presents the beneficial actions of ERβ signaling and clinical utility of several natural ERβ ligands as potential cancer therapy.

关 键 词：Estrogen receptor Estrogen receptor beta Tumor suppressor ER beta agonists LIQUIRITIGENIN S-equol GENISTEIN 

分 类 号：R965[医药卫生—药理学]