LIQUIRITIGENIN

作品数：15被引量：81H指数：6
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相关领域：医药卫生更多>>
相关作者：刘雨欣郑汉其潘宣张勇孔令东更多>>
相关机构：北京大学南京医科大学香港中文大学南京大学更多>>
相关期刊：《Chinese Herbal Medicines》《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》《Journal of Chinese Pharmaceutical Sciences》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金更多>>
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Retraction: Liquiritigenin Inhibits Colorectal Cancer Proliferation, Invasion, and Epithelial-to-Mesenchymal Transition by Decreasing Expression of Runt-Related Transcription Factor 2
《Oncology Research》2024年第8期1373-1373,共1页Oncology Research Editorial Office 
Following the publication,concerns have been raised about a number of figures in this article.The western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in man...
关键词：Cancer raised Transition 
Liquiritigenin promotes osteogenic differentiation and prevents bone loss via inducing auto-lysosomal degradation and inhibiting apoptosis
《Genes & Diseases》2023年第1期284-300,共17页Yu Qiu Yueyang Zhao Zhimin Long Aijia Song Peng Huang Kejian Wang Ling Xu David Paul Molloy Guiqiong He 
This study was supported by the National Natural Science Foundation of China(No.81671257,81371221,31600825)81671257,81371221,31600825);Innovation Research Group at Institutions of Higher Education in Chongqing,China(No.CXQTP19019019034)Program for Innovation Team Building at Institutions of Higher Education in Chongqing in 2016.
Osteoporosis(OP)is a debilitating skeletal abnormality involving bone remodeling and bone cell homeostasis characterized by decreased bone strength and high fracture risk.A novel therapeutic intervention for OP by man...
关键词：APOPTOSIS Auto-lysosomal degradation LIQUIRITIGENIN Osteogenic differentiation OSTEOPOROSIS 
Combined treatment with valproic acid and estrogen has neuroprotective effects in ovariectomized mice with Alzheimer’s disease被引量：4
《Neural Regeneration Research》2021年第10期2078-2085,共8页Yan-Zhen Li Yuan-Jie Liu Wei Zhang Shi-Fang Luo Xin Zhou Gui-Qiong He 
This study was supported by the National Natural Science Foundation of China,Nos.81671257,81371221,31600825(all to GQH).
Postmenopausal women with Alzheimer’s disease exhibit dramatically reduced sensitivity to estrogen replacement therapy,which is though to be related to an estrogen receptor(ER)α/ERβratio imbalance arising from a si...
关键词：17Β-ESTRADIOL amyloidβ dementia estrogen receptorα estrogen receptorβ glycogen synthase kinase-3β LIQUIRITIGENIN MENOPAUSE neuron loss tau 
Development of liquiritigenin-phospholipid complex with the enhanced oral bioavailability被引量：2
《Chinese Journal of Natural Medicines》2020年第12期916-921,共6页SHI Chang-Can QIN Kun-Ming XU Ke CHEN An CAI Ting CAI Bao-Chang 
In the present study,liquiritigenin-phospholipid complex(LPC)was developed and evaluated to increase the oral bioavailability of liquiritigenin.A single-factor test methodology was applied to optimize the formulation ...
关键词：LIQUIRITIGENIN Liquiritigenin-phospholipid complex SOLUBILITY CHARACTERIZATION Cioavailability 
De novo biosynthesis of liquiritin in Saccharomyces cerevisiae被引量：11
《Acta Pharmaceutica Sinica B》2020年第4期711-721,共11页Yan Yin Yanpeng Li Dan Jiang Xianan Zhang Wei Gao Chunsheng Liu 
supported by the National Natural Science Foundation of China(No.81773838);the National Program for Special Support of Eminent Professionals;the Key Project at central government level(No.2060302,China).
Liquiritigenin(LG),isoliquiritigenin(Iso-LG),together with their respective glycoside derivatives liquiritin(LN)and isoliquiritin(Iso-LN),are the main active flavonoids of Glycyrrhiza uralensis,which is arguably the m...
关键词：GLYCYRRHIZA uralensis LIQUIRITIN ISOLIQUIRITIN LIQUIRITIGENIN ISOLIQUIRITIGENIN HETEROLOGOUS synthesis Saccharomyces cerevisiae 
反相二维色谱制备甘草中黄酮类化合物被引量：9
《中草药》2018年第9期2033-2040,共8页朱靖博 籍立新 萧伟 丁燕 黄文哲 屠鹏飞 王永华 
国家自然科学基金-联合基金项目(U1603285);辽宁省教育厅基本科研项目(2016J008);江苏省"双创计划"项目(苏人才[2015]26号);连云港市"高层次创新创业领军人才集聚工程"资助(连人才[2016]1号)
目的构建甘草黄酮类化合物系统性分离制备方法。方法采用特异性吸附材料富集甘草中的黄酮类化合物,以自主研发的制备色谱工厂系统,采用色谱分离专家系统软件优化分离制备条件,通过上样量和富集次数等参数的考察,建立了基于分离富集模式...
关键词：反相二维色谱 甘草 黄酮类化合物 色谱分离专家系统 甘草苷 甘草素 芒柄花黄素 刺甘草查耳酮 7 4′-二羟基黄酮 4′-O-[β-D-apio-D-furanosyl-(1→2)-β-D-glucopyranosyl]liquiritigenin 异甘草素 甘草酚 甘草香豆素 
Chemical Constituents from Roots of Millettia speciosa被引量：11
《Chinese Herbal Medicines》2016年第4期385-389,共5页Man-qin Fu Geng-sheng Xiao Yu-juan Xu Ji-jun Wu Yu-long Chen Samuel-X Qiu 
Project of Chinese 12th Five-year Science and Technology(No.2015BAD16B09);Guangdong Natural Science Foundation(No.2015A030310284);Project of Chinese Public Welfare Industry Special(Agriculture) Research(No.201503142-03)
Objective To study the chemical constituents from the roots of Millettia speciosa.Methods The chemical constituents were isolated and purified by silica gel, Sephadex LH-20, and ODS column chromatography. The structur...
关键词：Leguminosae liquiritigenin Millettia speciosa naringenin 
LC–MS/MS Method for Quantification of Liquiritigenin in Rat Plasma: Application to Pharmacokinetic Study of Liquiritin被引量：2
《Chinese Herbal Medicines》2016年第1期53-60,共8页Shi-qi Dong Hui-rong Fan Quan-sheng Li Guang-li Wei Ya-zhuo Li Chang-xiao Liu Duan-yun Si 
"Twelfth Five-year Plan"-Major Technological Projects of "Creation of Major New Drug"(2012ZX09506-001);National 973 Program of China(2010CB933900);Tianjin Science and Technology Plan Project(10SYSYJC28600)
Objective A simple, sensitive, and rapid LC-MS/MS method has been established and validated for the determination of liquiritigenin （LG） in rat plasma. Methods Naringenin was chosen as internal standard （IS）. LG a...
关键词：LC-MS/MS LIQUIRITIGENIN LIQUIRITIN PHARMACOKINETICS 
Cancer therapy using natural ligands that target estrogen receptor beta被引量：5
《Chinese Journal of Natural Medicines》2015年第11期801-807,共7页Gangadhara R Sareddy Ratna K.Vadlamudi 
supported by the NIH/NCI grant CA178499-01(RKV);CPRIT Training grant RP140105(GRS);2014-15 ABTA Discovery grant(GRS)
Estrogen receptor beta(ERβ) is one of the two key receptors(ERα, ERβ) that facilitate biological actions of 17β-estradiol(E2). ERβ is widely expressed in many tissues, and its expression is reduced or lost during...
关键词：Estrogen receptor Estrogen receptor beta Tumor suppressor ER beta agonists LIQUIRITIGENIN S-equol GENISTEIN 
Development of a monolithic polymer pipette for solid-phase extraction of liquiritigenin in rat plasma被引量：5
《Chinese Chemical Letters》2012年第6期723-726,共4页Hong Wu Zhang Kang Li Zhi Xian Liang Feng YangWang Qi Wen Lu 
supports of the National Natural Science Foundation of China (No.30801515);the Scientific Research Foundation for the Returned Overseas Chinese Scholars,State Education Ministry(No.[2011]1139);the Open Fund of Key Laboratory of Analytical Chemistry for Living Biosystems, CAS(No.ACL201202)
A monolithic polymer column with mixed-mode interaction was prepared by in situ polymerization in a 1000μL pipette. Two kinds of monomers, butyl methacrylate （BMA） and 2-（dimethylamino）ethyl methacrylate （DMAM）...
关键词：Monolithic polymer pipette Solid phase extraction High performance liquid chromatography LIQUIRITIGENIN 
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