ISOLIQUIRITIGENIN

作品数：22被引量：95H指数：5
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Multidimensional screening of Astragalus membranaceus small molecules to mitigate carbon ion radiation-induced bystander effects
《Journal of Pharmaceutical Analysis》2024年第10期1531-1534,共4页Liying Zhang Yiming Zhang Yangyang Li Qiyang Li Shangzu Zhang Zhiming Miao Jinpeng He Ting Zhou Gengqiang Yang Xin Wang Jufang Wang Yongqi Liu 
This work was supported by the National Natural Science Foundation of China(Grant Nos.:82260882 and 82004094).
Existing studies have shown that Astragalus membranaceus(AM)and its active ingredients astragalus polysaccharides,oninon,and astragalus methyl glycosides can attenuate X-ray radiation-induced injury.However,there are ...
关键词：RADIOTHERAPY BMSCS HIF-1α Astragalus membranaceus ISOLIQUIRITIGENIN Non-small cell lung 
Exploring the molecular mechanism of Epimedium brevicornu Maxim.in treating breast cancer via network pharmacology and in vitro experiments
《Journal of Traditional Chinese Medical Sciences》2024年第2期207-221,共15页Xuan Wang Bin Cui Liuyan Xu Xiaohua Pei 
supported by the National Natural Science Foundation of China(81774319).
Objective:To evaluate the therapeutic effects of Epimedium brevicornu Maxim.(EBM,Yin Yang Huo)on breast cancer using network pharmacology and in vitro validation.It also aimed to explore the novel targets and mechanis...
关键词：Breast cancer Epimedium brevicornu Maxim Molecular docking β-Anhydroicaritin ISOLIQUIRITIGENIN Flow cytometry MDA-MB-231 
Charge adaptive phytochemical-based nanoparticles for eradication of methicillin-resistant staphylococcus aureus biofilms
《Asian Journal of Pharmaceutical Sciences》2024年第3期160-176,共17页Xilong Cui Fanhui Liu Shuang Cai Tingting Wang Sidi Zheng Xinshu Zou Linlin Wang Siqi He Yanhua Li Zhiyun Zhang 
supported by the National Natural Science Foundation of China(No.3210190403);the Natural Science Foundation of Heilongjiang Province(No.YQ2022C016);the China Postdoctoral Science Foundation(2022T150104and 2020M670877);the Postdoctoral Science Foundation of Heilongjiang Province(LBH-TZ2104 and LBH-Z20039);the China Agriculture Research System of MOF and MARA(No.CARS-35)。
The intrinsic resistance of MRSA coupled with biofilm antibiotic tolerance challenges the antibiotic treatment of MRSA biofilm infections.Phytochemical-based nanoplatform is a promising emerging approach for treatment...
关键词：MRSA biofilm ISOLIQUIRITIGENIN Dimer prodrug Charge adaptive Responsive nanoparticles 
Isoliquiritigenin regulated ox-LDL through activating the PPAR-γ signaling pathway to stabilize atherosclerosis plaques
《Journal of Hainan Medical University》2023年第18期7-14,共8页XU Xin-rui GAO Zhao ZHANG Qing-yue YANG Man-fang SUN Hao FENG Lu WANG Tian-yu LI Yang LOU Li-xia WU Ai-ming NIE Bo 
National Natural Science Foundation of China(No.82274488,81874446)。
Objective:To explore the molecular mechanisms of isoliquiritigenin in stabilizing atherosclerotic plaques by activating PPAR-γsignal pathway to regulate ox-LDL metabolism.Methods:The ApoE-/-mice AS carotid plaque mod...
关键词：Atherosclerosis mice ISOLIQUIRITIGENIN OX-LDL PPAR-Γ Plaque stability 
Isoliquiritigenin induces HMOX1 and GPX4-mediated ferroptosis in gallbladder cancer cells被引量：3
《Chinese Medical Journal》2023年第18期2210-2220,共11页Zeyu Wang Weijian Li Xue Wang Qin Zhu Liguo Liu Shimei Qiu Lu Zou Ke Liu Guoqiang Li Huijie Miao Yang Yang Chengkai Jiang Yong Liu Rong Shao Xu’an Wang Yingbin Liu 
supported by grants from the National Natural Science Foundation of China(Nos.3213000192,81874181,and 31620103910);the Science and Technology Commission of Shanghai Municipality(No.20JC1419101).
Background:Gallbladder cancer(GBC)is the most common malignant tumor of biliary tract.Isoliquiritigenin(ISL)is a natural compound with chalcone structure extracted from the roots of licorice and other plants.Relevant ...
关键词：ISOLIQUIRITIGENIN Ferroptosis Gallbladder cancer HMOX1 GPX4 
Isoliquiritigenin inhibits Ishikawa endometrial carcinoma cells proliferation and promotes apoptosis
《解剖学杂志》2021年第S01期191-191,共1页Yao Lijie Jiang Yang Ma Yong Guo Linna Jin Haifeng 
Endometrial cancer is the fourth most frequent neoplasia i women worldwide,and the molecular mechanisms involved in the etiology and pathogenesis continue to be investigated.Isoliquiritigenin(ISL),an important flavono...
关键词：ENDOMETRIAL GLYCYRRHIZA PATHOGENESIS 
Isoliquiritigenin inhibits TGF-β1-induced fibrogenesis through activating autophagy via PI3K/AKT/mTOR pathway in MRC-5 cells被引量：23
《Acta Biochimica et Biophysica Sinica》2020年第8期810-820,共11页Jinjuan He Hao Peng Meifang Wang Ying Liu Xingrong Guo Bin Wang Longjun Dai Xueqin Cheng Zhongji Meng Leyong Yuan Fenglin Cai Yijun Tang 
This work was supported by the grants from the National Natural Science Foundation of China(No.81270092);the Free Exploration Fundation of Hubei University of Medicine(No.FDFR201801).
Isoliquiritigenin(ISL),a natural flavonoid derived from the root of liquorice,has been reported to possess anti-inflammatory and antioxidant activities.Previous studies have found that ISL plays a crucial role in anti...
关键词：ISOLIQUIRITIGENIN TGF-Β1 AUTOPHAGY pulmonary fibrosis PI3K/AKT mTOR 
De novo biosynthesis of liquiritin in Saccharomyces cerevisiae被引量：11
《Acta Pharmaceutica Sinica B》2020年第4期711-721,共11页Yan Yin Yanpeng Li Dan Jiang Xianan Zhang Wei Gao Chunsheng Liu 
supported by the National Natural Science Foundation of China(No.81773838);the National Program for Special Support of Eminent Professionals;the Key Project at central government level(No.2060302,China).
Liquiritigenin(LG),isoliquiritigenin(Iso-LG),together with their respective glycoside derivatives liquiritin(LN)and isoliquiritin(Iso-LN),are the main active flavonoids of Glycyrrhiza uralensis,which is arguably the m...
关键词：GLYCYRRHIZA uralensis LIQUIRITIN ISOLIQUIRITIN LIQUIRITIGENIN ISOLIQUIRITIGENIN HETEROLOGOUS synthesis Saccharomyces cerevisiae 
Anticancer activity of Isoliquiritigenin: biological effects and molecular mechanisms被引量：2
《Journal of Chinese Pharmaceutical Sciences》2019年第10期673-686,共14页Wenxiu Xin Qilu Fang Jiao Sun Sisi Kong Lingya Chen Ping Huang 
Chinese Medicine Research Program of Zhejiang Province(Grant No.2016ZA035);Projects of Medical and Health Technology Program in Zhejiang Province(Grant No.2016KYA053);Zhejiang Provincial Association of Integrative Medicine Research Fund Project(Grant No.2016LYK020)
Natural compounds derived from plants have attracted considerable attention in the scientific community due to their nontoxic nature and anti-cancer activity.Isoliquiritigenin(ISL),an active flavonoid isolated from th...
关键词：CANCER ISOLIQUIRITIGENIN EFFECT MECHANISM 
异甘草素对人肾透明细胞癌786-O细胞抗癌作用及分子机制被引量：15
《中国实验方剂学杂志》2019年第12期83-89,共7页辛红 孙鹏然 宋鹏 徐巍 
黑龙江省教育厅科研项目(10541149)
目的:研究异甘草素(isoliquiritigenin,ISL)对人肾透明细胞癌786-O细胞的抗癌作用,并探讨其可能存在的分子机制。方法:通过噻唑蓝(thiazolyl blue tetrazolium bromide,MTT)比色法检测ISL(0,10,25,50,75,100μmol·L^(-1))对786-O细胞...
关键词：异甘草素(isoliquiritigenin) 肾透明细胞癌 786-O细胞 自噬 磷脂酰肌醇-3-激酶/蛋白激酶B/哺乳动物雷帕霉素蛋白(PI3K/Akt/mTOR)信号通路 
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