HETEROLOGOUS

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相关机构：山东大学中国科学院上海生命科学研究院南京林业大学中国科学院植物研究所更多>>
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Heterologous activation and metabolites identification of the pks7 gene cluster from Saccharopolyspora erythraea
《Synthetic and Systems Biotechnology》2024年第4期828-833,共6页Hao Tang Xingchi Yang Wenzong Wang Xingjun Cui Wenping Wei Jing Wu Peng Sun Bang-Ce Ye 
support from the National Key Research and Development Program of China(Nos.2018YFA0900404 and 2022YFC2804105);the National Natural Science Foundation of China(No.82273849).
The microbial genome remains a huge treasure trove for the discovery of diverse natural products.Saccharopolyspora erythraea NRRL23338,the industry producer of erythromycin,has a dozen of biosynthetic gene clusters wh...
关键词：Heterologous expression Saccharopolyspora erythraea 6-Methylsalicyclic acid 6-Ethylsalicyclic acid 6-Ethylsalicyclic acid ester derivatives Flavonoid 
Stepwise increase of fidaxomicin in an engineered heterologous host Streptomyces albus through multi-level metabolic engineering
《Synthetic and Systems Biotechnology》2024年第4期766-774,共9页Huang Xie Yi-Ting Su Qing-Ting Bu Yue-Ping Li Qing-Wei Zhao Yi-Ling Du Yong-Quan Li 
supported by the National Key R&D Program of China(grant number 2019YFA09005400);the Zhejiang Provincial Natural Science Foundation of China(grant number LQ21C010002).
The anti-Clostridium difficile infection(CDI)drug fidaxomicin is a natural polyketide metabolite mainly produced by Micromonosporaceae,such as Actinoplanes deccanensis,Dactylosporangium aurantiacum,and Micromonospora ...
关键词：Fidaxomicin Heterologous expression Streptomyces albus Genome-reduced chassis Metabolic engineering 
Compound Danshen Yeast 1.0
《Science of Traditional Chinese Medicine》2024年第4期303-311,共9页Rongsheng Li Jie Wang Yuanyuan Han Zhubo Dai 
supported by National Key Research and Development Program of China(2020YFA0908000);Prof.Zhubo Dai was supported by Youth Innovation Promotion Association of CAS(2015138);Haihe Laboratory Disruptive Innovation Talent Program(22HHSWSS00026);supported by the Key Project at Central Government Level:The ability establishment of sustainable use for valuable Chinese medicine resources(2060302)。
Background:Heterologous synthesis presents a promising new approach for accessing the active ingredients of traditional Chinese medicine(TCM),contributing to the conservation of natural medicinal resources.Compound Da...
关键词：Heterologous biosynthesis Compound Danshen preparation Synthetic biology Saccharomyces cerevisiae Compound Danshen Yeast 1.0 
Heterologous biosynthesis of saponin adjuvants from Quillaja saponaria:A symbolic achievement in metabolic engineering
《Acta Pharmaceutica Sinica B》2024年第12期5518-5520,共3页Weiqiang Chen Zhichao Xu Wei Sun 
Heterologous production of pharmaceutically important plant nat-ural products(PNPs)in heterologous hosts is an attractive strategy for the sustainable use of the resources bestowed by nature.Over the past two decades,...
关键词：QS-21 QS-7 Plant natural products(PNPs) Heterologous biosynthesis 
Low Concentration of Wenyang Tonglin Decoction Promotes Conjugation and Transfer of Drug-Resistant Plasmids among Heterologous Strains
《Chinese Journal of Integrative Medicine》2024年第8期721-728,共8页WANG Bi-yan BU Hong-shi XIA Li-bo JIANG Xiang-yu TONG Yan-qing 
Supported by the National Natural Science Foundation of China(No.81873070)。
Objective To investigate the effect of low concentration of Wenyang Tonglin Decoction(WTD)on the binding conditions of R45 plasmid conjugative transfer under liquid phase conjugation and its mechanism.Methods Escheric...
关键词：urinary tract infection Chinese medicine drug-resistant plasmid heterozygous strains CONJUGATION transfer 
Intranasal boosting with RBD-HR protein vaccine elicits robust mucosal and systemic immune responses
《Genes & Diseases》2024年第4期327-339,共13页Li Chen Wenyan Ren Hong Lei Jiayu Wang Haiying Que Dandan Wan Aqu Alu Dandan Peng Minyang Fu Weiqi Hong Yuhe Huang Xiangrong Song Guangwen Lu Xiawei Wei 
funded by the National Science Foundation for Excellent Young Scholars of China(No.32122052);the National Natural Science Foundation Regional Innovation and Development of China(No.U19A2003).
The emergence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants has decreased the efficacy of SARs-CoV-2 vaccines in containing coronavirus disease 2019(CoVID-19)over time,and booster vaccination ...
关键词：Heterologous immunization Intranasal immunization mRNA vaccine SARS-CoV-2 Subunitprotein vaccine 
The biosynthetic pathway of the hallucinogen mescaline and its heterologous reconstruction
《Molecular Plant》2024年第7期1129-1150,共22页Paula Berman Luis Alejandro de Haro Ana-Rita Cavaco Sayantan Panda Younghui Dong Nikolay Kuzmich Gabriel Lichtenstein Yoav Peleg Hila Harat Adam Jozwiaki Jianghua Cai Uwe Heinig Sagit Meir Ilana Rogachev Asaph Aharoni 
fellowships from the Israel Ministry of Absorption and the Dean of the Plant Science Department in the Weizmann Institute.We thank Prof.David Nelson(University of Tennessee,USA)for the systematic naming of the cytochrome P450 enzymes characterized in this study;Shmuel Regev and The Regev Nursery(Beit Elazari,Israel)for help in differentiating among Lophophora species;Dr.Ziv Spiegelman for providing several N.benthamiana plants;XINTEZA(https://xinteza.com/)for funding this research;and the Adelis Foundation,the Leona M.and Harry B.Helmsley Charitable Trust,the Jeanne and Joseph Nissim Foundation for Life Sciences,Tom and Sondra Rykoff Family Foundation Research,Ron Sklare and the Raymond Burton Plant Genome Research Fund for supporting the A.A.laboratory。
Mescaline,among the earliest identified natural hallucinogens,holds great potential in psychotherapy treatment.Nonetheless,despite the existence of a postulated biosynthetic pathway for more than half a century,the sp...
关键词：mescaline Lophophora williamsi Peyote biosynthetic pathway de novo genome sequencing mo-lecular modeling 
Rational Engineering of Secondary Metabolic Pathways in a Heterologous Host to Enable the Biosynthesis of Hibarimicin Derivatives with Enhanced Anti-Melanomic Activity
《Engineering》2024年第7期113-123,共11页Xiangyang Liu Fei-Peng Zhao Tian Tian Wei-Chen Wang Zaizhou Liu Qiang Zhou Xian-Feng Hou Jing Wang Wenli Guo Shuangjun Lin Yasuhiro Igarashi Gong-Li Tang 
supported in part by grants from the National Key Research and Development Program of China(2018YFA0901900);the National Natural Science Foundation of China(22137009);the China Postdoctoral Science Foundation(2020M671271).
A 61-kb biosynthetic gene cluster(BGC),which is accountable for the biosynthesis of hibarimicin(HBM)B from Microbispora rosea subsp.hibaria TP-A0121,was heterologously expressed in Streptomyces coelicolor M1154,which ...
关键词：Hibarimicin BIOSYNTHESIS Heterologous expression Biosynthetic gene cluster Rational engineering Type-II polyketide 
Efficient heterologous biosynthesis of verazine,a metabolic precursor of the anti-cancer drug cyclopamine,in Nicotiana benthamiana
《Plant Communications》2024年第6期1-4,共4页Chengxi Kou Jingling Liu Xue Yin Di He Jia Liu Xin Hua Rui Ma Wei Sun Zheyong Xue Pengda Ma 
supported by the National Key Research and Development Program of China(2023YFA0915800);the Jilin Provincial Agricultural Science&Technology Innovation Project(CXGC202105GH).
Dear Editor,Among the large number of Veratrum steroid alkaloids(Zhang et al.,2020),cyclopamine has been shown to have various inhibitory mechanisms against cancer,including inhibition of the hedgehog signaling pathwa...
关键词：CYCLOPAMINE CANCER 
The structure-directing role of heterologous seeds in the synthesis of zeolite被引量：3
《Green Energy & Environment》2024年第5期792-801,共10页Haoyang Zhang Binyu Wang Wenfu Yan 
support from the National Key Research and Development Program of China(2021YFA1500401,2021YFA1501202);the National Natural Science Foundation of China(22288101);the 111 Project(B17020)for supporting this work.
Zeolites have been widely used as catalysts,ion-exchangers,and adsorbents in chemical industries,detergent industry,steel industry,glass industry,ceramic industry,medical and healthfield,and environmentalfield,and recen...
关键词：ZEOLITE Heterologous seed SYNTHESIS Structure-directing effect 
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