汉族、维吾尔族肾透明细胞癌患者血清差异氨基酸的比较  

Distinct expressions of serum amino acid in renal clear cell carcinoma between Han and Uygur nationalities

作　　者：夏韩 哈木拉提.吐送 王文光[1] 王玉杰[1] 张立东[1] 

机构地区：[1]新疆医科大学第一附属医院泌尿中心,乌鲁木齐830054

出　　处：《现代泌尿外科杂志》2015年第11期767-770,共4页Journal of Modern Urology

基　　金：国家自然科学基金(No.81060210);新疆维吾尔自治区自然科学基金重大项目(No.2013211A101);新疆医科大学校级科研项目(No.2012YFY28)

摘　　要：目的观察汉族与维吾尔族肾透明细胞癌患者之间血清氨基酸的变化,筛选差异氨基酸,并利用ROC曲线探讨差异氨基酸在两族肾透明细胞癌诊断中的临床价值。方法运用高效液相色谱法检测新疆地区96例肾透明细胞癌患者(汉族48例、维吾尔族48例)与96例健康人(汉族48例、维吾尔族48例)血清中的17种氨基酸含量,通过组间均值比较出两民族肾癌患者间的差异氨基酸,并运用ROC曲线评价差异氨基酸的诊断价值。结果汉、维两族肾透明细胞癌患者除谷氨酸外,其余氨基酸含量均降低,且差异具有统计学意义(P<0.05)。两族肾透明细胞癌患者之间存在差异的氨基酸为天冬氨酸、甘氨酸及络氨酸。三种差异氨基酸对应的汉族ROC曲线下面积为0.536、0.812及0.814,对应的维族ROC曲线下面积为0.676、0.804及0.876。结论新疆地区汉族与维族肾透明细胞癌患者之间有差异的血清氨基酸为天冬氨酸、甘氨酸及络氨酸。其中两民族均以络氨酸的AUC^(ROC)最大,诊断价值最高。Objective To observe the difference in serum amino acid in patients with renal clear cell carcinoma （RCCC） between Han and Uygur nationalities, and to screen differentially expressed serum amino acid, and to explore the diagnostic value of amino acid detection in RCCC. Methods High performance liquid chromatography （HPLC） was used to detect 17 kinds of amino acids in 96 RCCC cases （48 Han, 48 Uygur）, and in 96 healthy controls （48 Han, 48 Uygur）in Xinjiang region. The mean contents of amino acids were compared, and the diagnostic value of amino acids was assessed with ROC curve. Results Except for glutamic acid, the other amino acids were lower in RCCC patients than in healthy controls, and the difference was statistically significant （P〈0. 05）. There were differences in aspartate, glycine and tyrosine between the Han and Uygur RCCC patients. The area under ROC curve for the three amino acids was 0. 536, 0. 812 and 0. 814 for Han nationality, and 0. 676, 0. 804 and 0. 876 for Uygur nationality. Conclusion There were differences in serum aspartate, glycine and tyrosine between Han and Uygur RCCC patients. Tyrosine has the largest AUC ROC and highest diagnostic value.

关 键 词：肾癌 汉族 维吾尔族 氨基酸 生物学 

分 类 号：R737.1[医药卫生—肿瘤]