肝性脑病患者肠道菌群变化的临床研究  

Clinical Research on Intestinal Flora Changes in Patients with Hepatic Encephalopathy

作　　者：梁淑文[1] 屈昌民[1] 王晓英[1] 曹艳菊[1] 李连勇[1] 钟长青[1] 曾伯伦 谢明水[2] 

机构地区：[1]中国人民解放军第306医院消化内科,北京100101 [2]随州市中心医院,441300

出　　处：《医学研究杂志》2015年第11期68-70,共3页Journal of Medical Research

基　　金：湖北省自然科学基金资助项目(2013CFB480)

摘　　要：目的分析肝性脑病患者肠道菌群的变化情况，为临床肝性脑病的诊治提供参考和借鉴。方法从笔者医院2012年3月～2014年3月收治的80例乙型肝炎肝硬化患者中筛选出38例肝性脑病患者及42例肝硬化非肝性脑病患者，另选取40例同期在笔者医院体检的健康者作为健康对照组，对3组受试者肠道菌群进行比较和分析。结果肝性脑病组患者乳杆菌属及肠球菌属菌落数均显著低于非肝性脑病组及健康对照组，酵母样真菌属菌落数显著多于非肝性脑病组及健康对照组，差异均有统计学意义（P〈0．05）。非肝性脑病组患者菌群菌落数酵母样真菌属与健康对照组相比，差异无统计学意义（P〉0．05），乳杆菌属及肠球菌属均显著少于健康对照组（P〈0．05）。肝性脑病组患者双歧杆菌显著少于非肝性脑病组患者及健康对照组，大肠杆菌显著多于非肝性脑病组患者及健康对照组，差异有统计学意义（P〈0．05）。非肝性脑病组与健康对照组相比，差异无统计学意义（P〉0．05）。结论肝性脑病的患者存在肠道菌群失调，其可能是引起肝性脑病的重要因素，调节肠道菌群，保持肠道微生态平衡是治疗肝性脑病的重要策略。Objective To research the intestinal flora changes in patients with hepatic encephalopathy to provide reference for clini- cal diagnosis and treatment of hepatic encephalopathy. Methods We selected 80 patients of Hepatitis B cirrhosis from March 2012 who to March 2014 were divided into hepatic encephalopathy group （n = 38） and non - hepatic encephalopathy group （n = 42） , then selected 40 healthy persons in the same period into our hospital as the healthy control group differences of Intestinal flora between the two groups were compared. Results The colonies number of Lactobacillus and Enterococcus bacteria in hepatic enccphalopathy group were both lower than the other two groups （the healthy control group and the on - hepatic encephalopathy group） , the colonies number of yeast like fungi were higher （ P 〈 O. 05 ）. The colonies number of yeast like fungi in the other two groups had no statistical difference （ P 〉 0.05） , the col- onies number of Lactobacillus and Enterococcus bacteria in non - hepatic encephalopathy group were both lower than healthy control group （P 〈 0.05）. The colonies number of Bifidobacterium in hepatic encephalopathy group was lower and Escherichia coli was higher （ P 〈 0. 05）. Conclusion Intestinal flora existed in patients with hepatic encephalopathy, which may be an important factor in causing hepatic encephalopathy. Regulating of intestinal flora, maintaining intestinal microflora balance are the important strategy for the treatment of he- patic encephalopathy.

关 键 词：肝性脑病 肠道菌群 乳杆菌 肠球菌 

分 类 号：R575.5[医药卫生—消化系统]