片仔癀对乙醇代谢的影响  

Effects of Pien Tze Huang on alcohol metabolism

作　　者：洪绯 

机构地区：[1]福建漳州片仔癀药业股份有限公司,福建漳州363000

出　　处：《安徽中医药大学学报》2015年第6期72-74,共3页Journal of Anhui University of Chinese Medicine

摘　　要：目的研究片仔癀的解酒作用。方法将48只SD雄性大鼠随机分为正常对照组,模型组,片仔癀高、中、低剂量组,海王金樽对照组,每组8只。乙醇灌胃前0.5h,分别给予海王金樽300mg/kg,片仔癀组360、180、90mg/kg灌胃,正常对照组和模型组分别给予等容积生理盐水,乙醇灌胃后0.5、1、2、3、5h分别采用顶空气质联用仪测定血液乙醇含量。结果乙醇灌胃1h后,各组血中乙醇浓度达到峰值,5h后乙醇浓度降至最低值;片仔癀可明显降低血液中乙醇浓度,呈现明显的量效关系,以片仔癀低剂量的作用最优;低、中、高剂量片仔癀降低血中乙醇浓度的效应均明显优于海王金樽。结论片仔癀有促进乙醇代谢的作用。Objective To investigate the effects of Pien Tze Huang （PZH） in relieving alcoholism. Methods Forty-eight male Sprague-Dawley rats were equally and randomly divided into normal control group, model group, low-dose PZH group, middle-dose PZH group, high-dose PZH group, and Hai Wang Jin Zun （HWJZ） group （as a positive control）. The HWJZ group and the PZH groups were given HWJZ （300 mg/kg） and PZH （360 mg/kg, 180 mg/kg, 90 mg/kg）, respectively, by gavage, and then they were given alcohol （5 mL/kg） by gavage at 0.5 h after the treatments. The normal control group and the model group were given an equal volume of saline by gavage, and then they were given saline （5 mL/kg） and alcohol （5 mL/kg）, respectively, by gavage at 0.5 h after the treatments. The blood of all rats was collected to determine the content of alcohol at 0.5, 1, 2, 3, and 5 h after giving alcohol with headspace gas chromatography-mass spectrometer. Results At 1 h after giving alcohol, the content of alcohol in the blood reached the peak level, and then it fell along over time. The content was lowest at 5 h after giving alcohol. PZH significantly decreased the content of alcohol in the blood with a significant dose-effect relationship, and the low-dose PZH showed the best effect. The decrease in the content of alcohol in the blood was significantly larger in the PZH groups than in the HWJZ group. Conclusion PZH can promote the alcohol metabolism.

关 键 词：片仔癀 海王金樽 乙醇代谢 顶空气质联用仪 

分 类 号：R575.5[医药卫生—消化系统]