首发未治疗青少年抑郁症患者神经认知功能与性激素水平的关系  

The relationship between neuro-cognitive function and sex hormone concentration in adolescents with first-episode untreated depression

作　　者：黄雪竹[1] 杨勤[1] 任冬梅[1] 黄敏[1] 雷嗣鸿 李光明[1] 

机构地区：[1]川北医学院附属南充市中心医院心身医学科,四川南充637000

出　　处：《临床医药文献电子杂志》2015年第31期6363-6364,6366,共3页Electronic Journal of Clinical Medical Literature

摘　　要：目的对首发未治疗青少年抑郁症患者神经认知功能与性激素水平的关系进行分析。方法随机抽取于我院就诊的200例首发未治疗青少年抑郁症患者和按照性别、年龄配对的200名健康体检青少年,组成病例组和对照组。应用化学发光法对血清黄体酮、睾酮、雌二醇浓度进行检测;通过Raven测验对神经认知功能状态进行评价;分析神经认知功能状态与血液性激素浓度的关系。结果病例组男性治疗前睾酮水平比对照组低,病例组治疗前雌二醇水平比对照组低;病例组男性睾酮水平治疗后升高,病例组雌二醇水平治疗后升高。病例组男性治疗前Raven测验正确题数、知觉辨别能力随睾酮、雌二醇浓度升高而增加,智商和抽象推理能力随雌二醇浓度升高而增加;治疗后知觉辨别水平随黄体酮浓度升高而增加。病例组女性治疗前Raven测验正确题数、智商及抽象推理能力随血液黄体酮、睾酮浓度升高而增加,知觉辨别能力随血液黄体酮浓度升高而下降。病例组治疗后Raven测验正确题数随血液睾酮浓度升高而减少,随血液雌二醇浓度升高而增加;知觉辨别能力和抽象推理能力随血液睾酮浓度升高而下降;智商随血液睾酮浓度增加而减少,随血液雌二醇浓度增加而升高。结论首发未治疗青少年抑郁症患者神经认知水平和能力随血液性激素浓度变化而变化。经过3个月舍曲林抗抑郁治疗后,青少年抑郁症患者血液性激素浓度仍然存在部分异常。Objective To study the relationship between neuro-cognitive function and sex hormone level in adolescents with first-episode untreated depression. Method Randomly selected 200 adolescents with firstepisode untreated depression as case group, and 200 healthy subjects as control group. The concentation of serum progesterone, testosterone and estradiol were tested in control group and in case group before and after the 3-month treatment with sertraline. The neuro-cognitive function was evaluated with Raven test. Results Boys＇ serum concentration of testosterone in case group was elevated after treatment. The serum concentration of estradiol in case group was higher after treatment. The neuro-cognitive function was related to the concentration of serum sex hormone in case group by different direction before and after treatment. Conclusion The neuro-cognitive function of adolescents with first-episode untreated depression was influenced by serum concentration of sex hormone. There was still some deviation from normal range of serum concentration of sex hormone in adolescents with first-episode untreated depression after 3-month sertraline treatment.

关 键 词：青少年 抑郁 认知 激素 病理 预防 

分 类 号：R749.4[医药卫生—神经病学与精神病学]