Endogenous neurotrophin-3 promotes neuronal sprouting from dorsal root ganglia  

作　　者：Xu-yang Wang Pei-yuan Gu Shi-wen Chen Wen-wei Gao Heng-li Tian Xiang-he Lu Wei-ming Zheng Qi-chuan Zhuge Wei-xing Hu 

机构地区：[1]Department of Neurosurgery, First Affiliated Hospital of Nanjing Medical University [2]Department of Neurosurgery, Shanghai Jiao Tong University Affiliated 6th People’s Hospital [3]Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University

出　　处：《Neural Regeneration Research》2015年第11期1865-1868,共4页中国神经再生研究（英文版）

基　　金：supported by grants from the Shanghai Municipal Commission of Health and Family Planning;No.20114351;the Traditional Chinese Medicine Science Funding of Zhejiang Province of China;No.2010ZB091;the Natural Science Foundation of Zhejiang Province of China;No.Y2090864

摘　　要：In the present study, we investigated the role of endogenous neurotrophin-3 in nerve terminal sprouting 2 months after spinal cord dorsal root rhizotomy. The left L1-5 and L7-S2 dorsal root ganglia in adult cats were exposed and removed, preserving the L6 dorsal root ganglia. Neurotrophin-3 was mainly expressed in large neurons in the dorsal root ganglia and in some neurons in spinal lamina II. Two months after rhizotomy, the number of neurotrophin-3-positive neurons in the spared dorsal root ganglia and the density of neurite sprouts emerging from these ganglia were increased. Intraperitoneal injection of an antibody against neurotrophin-3 decreased the density of neurite sprouts. These findings suggest that endogenous neurotrophin-3 is involved in spinal cord plasticity and regeneration, and that it promotes axonal sprouting from the dorsal root ganglia after spinal cord dorsal root rhizotomy.In the present study, we investigated the role of endogenous neurotrophin-3 in nerve terminal sprouting 2 months after spinal cord dorsal root rhizotomy. The left L1-5 and L7-S2 dorsal root ganglia in adult cats were exposed and removed, preserving the L6 dorsal root ganglia. Neurotrophin-3 was mainly expressed in large neurons in the dorsal root ganglia and in some neurons in spinal lamina II. Two months after rhizotomy, the number of neurotrophin-3-positive neurons in the spared dorsal root ganglia and the density of neurite sprouts emerging from these ganglia were increased. Intraperitoneal injection of an antibody against neurotrophin-3 decreased the density of neurite sprouts. These findings suggest that endogenous neurotrophin-3 is involved in spinal cord plasticity and regeneration, and that it promotes axonal sprouting from the dorsal root ganglia after spinal cord dorsal root rhizotomy.

关 键 词：nerve regeneration NEUROTROPHIN-3 sensory neurons dorsal root ganglion CATS nerveterminal neural regeneration 

分 类 号：R741[医药卫生—神经病学与精神病学]