Mechanisms of action of BCL6 during germinal center B cell development  

作　　者：HUANG ChuanXin MELNICK Ari 

机构地区：[1]Shanghai Institute of Immunology & Department of Immunobiology and Microbiology, Shanghai Jiao Tong University School of Medicine [2]Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medical College

出　　处：《Science China(Life Sciences)》2015年第12期1226-1232,共7页中国科学（生命科学英文版）

摘　　要：The transcriptional repressor B cell lymphoma 6(BCL6) controls a large transcriptional network that is required for the formation and maintenance of germinal centers(GC). GC B cells represent the normal counterpart of most human B-cell lymphomas, which are often characterized by deregulated BCL6 expression or BCL6-mediated pathways. BCL6 suppresses gene transcription largely through recruitment of its co-repressors through its distinct repression domain. Understanding the precise biological roles of each repression domain in normal and malignant B cells is helpful for development of targeted inhibition of BCL6 functions that is emerging as the basis for design of anti-lymphoma therapies. This review focuses on recent progress in the molecular mechanisms of action of BCL6 in B cells and discusses remaining unresolved questions related to how these mechanisms are linked to normal and malignant B cell development.The transcriptional repressor B cell lymphoma 6（BCL6） controls a large transcriptional network that is required for the formation and maintenance of germinal centers（GC）. GC B cells represent the normal counterpart of most human B-cell lymphomas, which are often characterized by deregulated BCL6 expression or BCL6-mediated pathways. BCL6 suppresses gene transcription largely through recruitment of its co-repressors through its distinct repression domain. Understanding the precise biological roles of each repression domain in normal and malignant B cells is helpful for development of targeted inhibition of BCL6 functions that is emerging as the basis for design of anti-lymphoma therapies. This review focuses on recent progress in the molecular mechanisms of action of BCL6 in B cells and discusses remaining unresolved questions related to how these mechanisms are linked to normal and malignant B cell development.

关 键 词：BCL6 germinal center CO-REPRESSOR LYMPHOMA 

分 类 号：R733[医药卫生—肿瘤]