CO-REPRESSOR

作品数:12被引量:51H指数:5
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相关领域:生物学医药卫生更多>>
相关机构:中国科学院大学更多>>
相关期刊:《Science China(Life Sciences)》《World Journal of Cardiology》《World Journal of Biological Chemistry》《Molecular Plant》更多>>
相关基金:国家自然科学基金国家重点基础研究发展计划高等学校学科创新引智计划中国博士后科学基金更多>>
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Intestinal epithelial cell NCoR deficiency ameliorates obesity and metabolic syndrome
《Acta Pharmaceutica Sinica B》2024年第12期5267-5285,共19页Shaocong Hou Hengcai Yu Caihong Liu Andrew M.F.Johnson Xingfeng Liu Qian Jiang Qijin Zhao Lijuan Kong Yanjun Wan Xiaowei Xing Yibing Chen Jingwen Chen Qing Wu Peng Zhang Changtao Jiang Bing Cui Pingping Li 
supported by grants from the Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(2021-I2M-1-016,2016-I2M-1-011,2016-I2M-3-008 and 2017-I2M-1-008,China);the Special Research Fund for Central Universities,Peking Union Medical College(3332022047,China);the Beijing Outstanding Young Scientist Program(BJJWZYJH01201910023028,China);the National Natural Science Foundation of China(81703588,82473984,81622010,81770800,and 81874316);the CAMS Central Public-interest Scientific Institution Basal Research Fund(2017RC31009 and 2018PT35004,China);the Drug Innovation Major Project from the National Science and Technology Department(2018ZX09711001-003-005 and 2018ZX09711001-003-001,China);the National Key R&D Program of China(2017YFA0205400 and 2022YFC2505204,China).
Nuclear receptor corepressor(NCoR1)interacts with various nuclear receptors and regulates the anabolism and catabolism of lipids.An imbalance in lipid/energy homeostasis is also an important factor in obesity and meta...
关键词:Nuclear receptor co-repressor 1 Intestinal epithelium Metabolic syndrome PPAR alpha Liver X receptor THERMOGENESIS SUCCINATE CHOLESTEROL 
Mirids secrete a TOPLESS targeting protein to enhance JA-mediated defense and gossypol accumulation for antagonizing cotton bollworms on cotton plants
《Molecular Plant》2024年第11期1687-1701,共15页Yu-Pei Mu Dian-Yang Chen Yu-Jie Liu Ming-Yu Zhu Xian Zhang Yin Tang Jia-Ling Lin Mu-Yang Wang Xiao-Xia Shangguan Xiao-Ya Chen Chengshu Wang Ying-Bo Mao 
supported by Biological Breeding-Major Projects(2023ZD04070);the National Natural Science Foundation of China(32072430 and 32000221);the Science and Technology Commission of Shanghai Municipality(22ZR1469300 and 21ZR1471000).
Most coexisting insect species exhibit stunted growth compared to individual species on plants.This phenomenon reflects an interspecific antagonism drawing extensive attention,while the underlying mechanisms remain la...
关键词:oral secretion plant defense co-repressor TOPLESS MIRIDS Apolygus lucorum cotton bollworms Helicoverpa armigera 
The transcriptional co-repressor SEED DORMANCY 4-LIKE(At SDR4L)promotes the embryonic-to-vegetative transition in Arabidopsis thaliana
《Journal of Integrative Plant Biology》2022年第11期2075-2096,共22页Ting Wu Milad Alizadeh Bailan Lu Jinkui Cheng Ryan Hoy Miaoyu Bu Emma Laqua Dongxue Tang Junna He Dongeun Go Zhizhong Gong Liang Song 
funded by the National Science Foundation of China(31921001);the Beijing Outstanding University Discipline Program to Z.G.;UBC Four Year Doctoral Fellowship to M.A.;BC Graduate Scholarship to R.H.;Bio Talent/SWPP funding to R.H.and E.L.;UBC Kay Earle Memorial Botany Fund Fellowship to B.L.;NSERC RGPIN-2019-05039 and CFI JELF/BCKDF 38187 to L.S.
Repression of embryonic traits during the seedto-seedling phase transition requires the inactivation of master transcription factors associated with embryogenesis.How the timing of such inactivation is controlled is u...
关键词:ABI3 At SDR4L embryonic-to-vegetative phase transition LEC1 
GRK5 is an essential co-repressor of the cardiac mineralocorticoid receptor and is selectively induced by finerenone
《World Journal of Cardiology》2022年第4期220-230,共11页Celina M Pollard Malka S Suster Natalie Cora Alexandra M Carbone Anastasios Lymperopoulos 
BACKGROUND In the heart,aldosterone(Aldo)binds the mineralocorticoid receptor(MR)to exert damaging,adverse remodeling-promoting effects.We recently showed that G protein-coupled receptor-kinase(GRK)-5 blocks the cardi...
关键词:ALDOSTERONE Cardiac myocyte Finerenone G protein-coupled receptor kinase-5 Mineralocorticoid receptor antagonist Signal transduction 
Arabidopsis ECAP Is a New Adaptor Protein that Connects JAZ Repressors with the TPR2 Co-repressor to Suppress Jasmonate-Responsive Anthocyanin Accumulation被引量:5
《Molecular Plant》2020年第2期246-265,共20页Changjiang Li Lei Shi Yanan Wang Wei Li Binqing Chen Lei Zhu Ying Fu 
supported by the National Natural Science Foundation of China(grant no.31872662 and 91854119 to Y.F.);China Postdoctoral Science Foundation grant(2018M641532 to C.L.).
Suppression mechanisms mediated by transcriptional repressors commonly exist in diverse phytohormone signaling pathways.In Arabidopsis thaliana,JASMONATE-ZIM DOMAIN(JAZ)proteins are transcriptional repressors that fun...
关键词:JASMONATE signaling anthocyanin adaptor PROTEINS ECAP JAZ PROTEINS TPL/TPRs 
DELLA proteins interact with FLC to repress flowering transition被引量:12
《Journal of Integrative Plant Biology》2016年第7期642-655,共14页Mingzhe Li Fengying An Wenyang Li Mengdi Ma Ying Feng Xing Zhang Hongwei Guo 
supported by grants from the National Natural Science Foundation of China (91217305, 91017010 and 31270320);Ministry of Agriculture of China (2010ZX08010-002);the 111 project of Peking University
Flowering is a highly orchestrated and extremely ct critical process in a plant's life cycle. Previous study has ademonstrated that SUPPRESSOR OF OVEREXPRESSION OF pCONSTANS 1(SOC1) and FLOWERING LOCUS T(FT) inte...
关键词:ARABIDOPSIS CO-REPRESSOR DELLAs FLC FLOWERING 
Mechanisms of action of BCL6 during germinal center B cell development被引量:4
《Science China(Life Sciences)》2015年第12期1226-1232,共7页HUANG ChuanXin MELNICK Ari 
The transcriptional repressor B cell lymphoma 6(BCL6) controls a large transcriptional network that is required for the formation and maintenance of germinal centers(GC). GC B cells represent the normal counterpart of...
关键词:BCL6 germinal center CO-REPRESSOR LYMPHOMA 
The molecular mechanism of SPOROCYTELESS/NOZZLE in controlling Arabidopsis ovule development被引量:10
《Cell Research》2015年第1期121-134,共14页Baoye Wei Jinzhe Zhang Changxu Pang Hao Yu Dongshu Guo Hao Jiang Mingxin Ding Zhuoyao Chen Qing Tao Hongya Gu Li-Jia Qu Genji Qin 
We thank Dr Yunde Zhao (University of California at San Diego, USA) for valuable suggestions. We thank Dr Jeff Long (University of California, Los Angeles, USA) and Dr Tomotsugu Koyama (Kyoto University, Japan) for kindly providing the seeds of tpl-1 and tcp3 tcp4 tcp5 tcp10. This work was supported by the National Key Basic Research Program of China (973- 2012CB944801), the National Natural Science Foundation of China (31270321), and National Transformation Science and Technology Program (2014ZX08009003-003-003). This work was also partially supported by the 111 Project (B06001).
Ovules are essential for plant reproduction and develop into seeds after fertilization. SPOROCYTELESS/NOZZLE (SPL/NZZ) has been known for more than 15 years as an essential factor for ovule development in Arabidopsi...
关键词:SPOROCYTELESS/NOZZLE transcriptional repressor TPL/TPR co-repressors TCP transcription factors SPOROGENESIS 
KAPtain in charge of multiple missions: Emerging roles of KAP1被引量:5
《World Journal of Biological Chemistry》2014年第3期308-320,共13页Chun-Ting Cheng Ching-Ying Kuo David K Ann 
KAP1/TRIM28/TIF1β was identified nearly twenty years ago as a universal transcriptional co-repressor because it interacts with a large KRAB-containing zinc finger protein(KRAB-ZFP) transcription factor family. Many s...
关键词:KRAB domain-associated PROTEIN 1 TRANSCRIPTIONAL CO-REPRESSOR POST-TRANSLATIONAL modification CHROMATIN remodeling KRAB-containing zinc finger PROTEIN 
Yin Yang 1(YY1) synergizes with Smad7 to inhibit TGF-β signaling in the nucleus被引量:11
《Science China(Life Sciences)》2014年第1期128-136,共9页YAN XiaoHua PAN Jun XIONG WanWan CHENG MinZhang SUN YingYuan ZHANG SuPing CHEN YeGuang 
supported by the National Natural Science Foundation of China(91019003);National Basic Research Program of China(2011CB943803 and 2013CB933701)
As a prototype of the TGF-β superfamily cytokines, TGF-β is well known for its diverse roles in embryogenesis and adult tis- sue homeostasis. TGF-β evokes cellular responses by signaling mainly through cell membran...
关键词:TGF-Β SMAD7 YY1 HDAC1 signaling regulation transcriptional co-repressor 
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