supported by grants from the Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(2021-I2M-1-016,2016-I2M-1-011,2016-I2M-3-008 and 2017-I2M-1-008,China);the Special Research Fund for Central Universities,Peking Union Medical College(3332022047,China);the Beijing Outstanding Young Scientist Program(BJJWZYJH01201910023028,China);the National Natural Science Foundation of China(81703588,82473984,81622010,81770800,and 81874316);the CAMS Central Public-interest Scientific Institution Basal Research Fund(2017RC31009 and 2018PT35004,China);the Drug Innovation Major Project from the National Science and Technology Department(2018ZX09711001-003-005 and 2018ZX09711001-003-001,China);the National Key R&D Program of China(2017YFA0205400 and 2022YFC2505204,China).
Nuclear receptor corepressor(NCoR1)interacts with various nuclear receptors and regulates the anabolism and catabolism of lipids.An imbalance in lipid/energy homeostasis is also an important factor in obesity and meta...
supported by Biological Breeding-Major Projects(2023ZD04070);the National Natural Science Foundation of China(32072430 and 32000221);the Science and Technology Commission of Shanghai Municipality(22ZR1469300 and 21ZR1471000).
Most coexisting insect species exhibit stunted growth compared to individual species on plants.This phenomenon reflects an interspecific antagonism drawing extensive attention,while the underlying mechanisms remain la...
funded by the National Science Foundation of China(31921001);the Beijing Outstanding University Discipline Program to Z.G.;UBC Four Year Doctoral Fellowship to M.A.;BC Graduate Scholarship to R.H.;Bio Talent/SWPP funding to R.H.and E.L.;UBC Kay Earle Memorial Botany Fund Fellowship to B.L.;NSERC RGPIN-2019-05039 and CFI JELF/BCKDF 38187 to L.S.
Repression of embryonic traits during the seedto-seedling phase transition requires the inactivation of master transcription factors associated with embryogenesis.How the timing of such inactivation is controlled is u...
BACKGROUND In the heart,aldosterone(Aldo)binds the mineralocorticoid receptor(MR)to exert damaging,adverse remodeling-promoting effects.We recently showed that G protein-coupled receptor-kinase(GRK)-5 blocks the cardi...
supported by the National Natural Science Foundation of China(grant no.31872662 and 91854119 to Y.F.);China Postdoctoral Science Foundation grant(2018M641532 to C.L.).
Suppression mechanisms mediated by transcriptional repressors commonly exist in diverse phytohormone signaling pathways.In Arabidopsis thaliana,JASMONATE-ZIM DOMAIN(JAZ)proteins are transcriptional repressors that fun...
supported by grants from the National Natural Science Foundation of China (91217305, 91017010 and 31270320);Ministry of Agriculture of China (2010ZX08010-002);the 111 project of Peking University
Flowering is a highly orchestrated and extremely ct critical process in a plant's life cycle. Previous study has ademonstrated that SUPPRESSOR OF OVEREXPRESSION OF pCONSTANS 1(SOC1) and FLOWERING LOCUS T(FT) inte...
The transcriptional repressor B cell lymphoma 6(BCL6) controls a large transcriptional network that is required for the formation and maintenance of germinal centers(GC). GC B cells represent the normal counterpart of...
We thank Dr Yunde Zhao (University of California at San Diego, USA) for valuable suggestions. We thank Dr Jeff Long (University of California, Los Angeles, USA) and Dr Tomotsugu Koyama (Kyoto University, Japan) for kindly providing the seeds of tpl-1 and tcp3 tcp4 tcp5 tcp10. This work was supported by the National Key Basic Research Program of China (973- 2012CB944801), the National Natural Science Foundation of China (31270321), and National Transformation Science and Technology Program (2014ZX08009003-003-003). This work was also partially supported by the 111 Project (B06001).
Ovules are essential for plant reproduction and develop into seeds after fertilization. SPOROCYTELESS/NOZZLE (SPL/NZZ) has been known for more than 15 years as an essential factor for ovule development in Arabidopsi...
KAP1/TRIM28/TIF1β was identified nearly twenty years ago as a universal transcriptional co-repressor because it interacts with a large KRAB-containing zinc finger protein(KRAB-ZFP) transcription factor family. Many s...
supported by the National Natural Science Foundation of China(91019003);National Basic Research Program of China(2011CB943803 and 2013CB933701)
As a prototype of the TGF-β superfamily cytokines, TGF-β is well known for its diverse roles in embryogenesis and adult tis- sue homeostasis. TGF-β evokes cellular responses by signaling mainly through cell membran...